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#5
PPBG in Non Diabetic
Patients can Predict Cardiovascular Events in Older Adults
Using
the 2 hour Postprandial blood glucose can help predict which
patients are at greater risk of strokes and MI.
Dr.
Nicholas L. Smith, from the University of Washington, Seattle, and
associates collected data on 4014 community-dwelling adults, 65
years of age or older, who participated in the Cardiovascular
Health Study. At baseline these subjects had no treated diabetes
and no history of MI or stroke.
What
they found and
reported on Feb 06 was that compared with fasting glucose levels
alone, the 2-hour postchallenge glucose level is better at
identifying older patients who are at risk of major cardiovascular
events.
During
a median 8.5 years of followup there were 764 cardiovascular
events, including 359 MIs, 348 cases of incident cerebrovascular
disease, and 117 deaths from CAD (60 subjects had both
cerebrovascular disease and CAD), according to the report in the
January 28th issue of the Archives of Internal Medicine.
In
adjusted analysis, the researchers found that fasting glucose
levels of 115 mg/dL or more were linked with an increased risk for
cardiovascular events (hazard ratio 1.66), relative to levels less
than 115 mg/dL.,
Analysis
of 2-hour postchallenge glucose levels adjusted for age, sex, and
race revealed that for every 10 mg/dL increase in level there was
a 2% increase in the risk of a cardiovascular event (ie, hazard
ratio 1.02). At a 2-hour glucose level of 154 mg/dL or more the
hazard ratio for incident cardiovascular events was 1.29, Dr.
Smith's team notes.
In
combined analysis of both fasting and 2-hour glucose levels, only
the latter remained predictive of cardiovascular events, the
investigators add.
They
conclude that "although a 2-hour measure of glycemia is
burdensome in routine clinical practice, it may serve a role in
identifying older adults at increased risk of incident
cardiovascular events."
Arch Intern Med 2002;162:209-216.
================================
DID
YOU KNOW?
The annual
incidence of type 1 diabetes in the U.S. is approximately 18 new
cases per 100,000 people younger than 20. Source Diabetes 2001: vital Stats Pg 78
By
referring your friends and colleagues to Diabetes in Control you
can win a free scholarship or expense check for the 2002 AADE
conference in Philadelphia.
http://www.diabetesincontrol.com/scholorship.shtml
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