Item #1
Onset
of Type 2 Diabetes Reduced 58% With Lifestyle Changes, Metformin
Treating
IGT and IFG patients can both reduce the incidence of type 2
diabetes in high-risk men and women and delay the complications
from diabetes
That,
according to the results of a randomized trial reported in The New
England Journal of Medicine for February 7.
Impaired
Glucose Tolerance (IGT) is a blood glucose of greater than 140 and
lower than 200mg/dl 2 hours after a meal or anytime if it is over
140mg/dl.
Impaired
Fasting Glucose (IFG) is a fasting blood glucose of greater than
110 and less then 126mg/dl. Both
IGT and IFG are signs of high blood sugars, but not high enough to
diagnose the patient with diabetes.
Should
IGT and IFG be designated as a disease so we can treat to target
and prevent or delay the diagnosis of diabetes which would prevent
or delay the complications from diabetes?????? Click
here to reply
Dr.
William C. Knowler from the Southwest American Indian Center for
Diabetes Prevention, Phoenix, and colleagues with the Diabetes
Prevention Program Research Group, studied 3232 nondiabetic men
and women, mean age 51 years, with elevated fasting and post-load
plasma glucose levels. Mean body mass index of the subjects was
34.0 kg/m .
The
subjects were randomly assigned to placebo, metformin 850 mg twice
daily, or to a lifestyle intervention program aimed at achieving
at least a 7% reduction in weight and 150 minutes of physical
activity per week.
During
the average follow-up of 2.8 years the incidence of diabetes was
11.0 cases per 100 person-years in patients receiving placebo, 7.8
among those receiving metformin and 4.8 for those in the weight
loss and exercise program, the researchers report.
The
incidence of diabetes was reduced by 58% among those in the weight
loss and exercise program and by 31% for those in the metformin
group, compared with the placebo group. The lifestyle program was
significantly more effective than metformin therapy in all age
groups (p < 0.05), Dr. Knowler's team notes.
Dr.
Knowlers Team notes that,” it is not necessary to wait until a
person has type 2 diabetes to begin doing something about it. The
hope is that if we can provide some intervention at an early
stage, before people have overt diabetes, they can avoid getting
diabetes," he said.
"The
lifestyle intervention was particularly effective, with one case
of diabetes prevented per seven persons treated for 3 years,' Dr.
Knowler pointed out. "Thus, it should also be possible to
delay or prevent the development of complications, substantially
reducing the individual and public health burden of
diabetes." N
Engl J Med 2002;346:393-403.
====================================================
DID
YOU KNOW?
There
are over 25 million people in the US with IGT (Source: Diabetes
2001 Vital Statistics)
AND
Diabetes In Control Has Over 1100
Studies & Articles In Our Archives, Which Allows You To Do A
Search On Any Topic! Just go to: http://www.diabetesincontrol.com/search.shtml
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