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Item
#3
Long-Term
Efficacy Of Metformin In Type 2 Diabetes?
Little data is available on the long-term
efficacy of one of the main drugs in the treatment
of type 2 diabetes, metformin.
This was a retrospective study of 195 type 2 diabetic
patients (109 female, 86 male; mean age 50.4±10.1
years, diabetes duration 5.4±1.4 years, mean
BMI 28.6±6.5 kg/m2 at baseline). The inclusion
criterion was at least one-year treatment with metformin
alone or metformin and one other antidiabetic drug
in unchanged doses. The analysis included duration
of metformin treatment, mode of therapy, changes
in metabolic parameters (fasting blood glucose,
HbA1c), body weight, and insulin dosage.
Mean duration of metformin use was 970±578
(range 373–2916) days, mostly 500 mg tid.
42 patients (22%) were treated with metformin only,
82 (42%) with metformin and sulfonylurea, 61 (31
%) with metformin and insulin and 10 (5%) with metformin
and acarbose. In the whole group mean fasting blood
glucose decreased during the treatment significantly,
from 212±57 to 167±54 mgldl (p<0.00001),
HbA1c from 9.3±1.3 to 8.5±1.1% (p<0.05),
body weight from 92.6±17.9 to 88.4±14.9
(by 4.5%; p<0.001). A significant positive correlation
was noted between baseline body weight and body
weight change (r=0.39; p<0.05). Insulin requirement
was reduced by a mean of 21 IU/day in the third
year of treatment.
In conclusion, metformin is an efficacious long-term
use drug in poorly controlled type 2 diabetes patients,
either in monotherapy or in combination. Med Sci
Monit, 2003; 9(6): CR240-243
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