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Item
#3
Diabetes
Increases Risk of Idiopathic Pulmonary Fibrosis
Pulmonary Fibrosis Added to list of diseases
those with diabetes are at increased risk for.
Results of a study published in the June issue of
Chest suggest that diabetes mellitus may be a risk
factor for idiopathic pulmonary fibrosis (IPF).
Dr. Tatsuji Enomoto of Nippon Medical School in
Tokyo and colleagues conducted a case-control study
of 65 consecutive patients hospitalized with IPF
and 184 controls to determine whether diabetes influences
the initiation or progression of IPF
The team reviewed information on age, sex, smoking
history, and results of physical examinations, blood
examinations, and lung function tests.
A total of 84.6% of patients were ever-smokers,
compared with 50.5% of controls. Diabetes was diagnosed
in 32.7% of patients and 11.4% of controls. A history
of smoking and diabetes were both associated with
a significantly increased prevalence of IPF (adjusted
odds ratios 5.40 and 4.06, respectively).
When the researchers looked at differences between
IPF patients with and without diabetes, Dr. Enomoto
and colleagues found that "only fasting blood
sugar (145.6 g/dL versus 92.0 g/dL) and HbA1c (6.26%
versus 5.32%), respectively, were different between
the two groups."
Although the team's results support the hypothesis
that diabetes increases the risk of IPF, the reasons
for this association are "unclear," they
acknowledge, calling for further large-scale studies
to clarify the connection. Chest 2003; 123:2007-2011
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