ADA: Improved Fat Oxidation After
Exercise Improved Insulin Sensitivity (IS)
Improved Fat Oxidation Following Exercise and
Weight Loss (EX+WL) Predicts Improved Insulin
Sensitivity (IS) in Obesity.
Decreased IS in skeletal muscle in obesity entails
dysregulation of both glucose and fatty acid metabolism,
a combination of metabolic impairments characterized
as metabolic inflexibility within skeletal muscle.
This study examined whether a EX+WL intervention
in obesity, one that generally enhances IS, also
mediates improved fasting rates of fat oxidation
(FOX).
Obese (BMI>30 kg´m-2) volunteers (9 men
and 16 women) without diabetes, aged 39±4.3
years completed a 16 weeks of moderate intensity
EX (4-5 sessions/week, 30-50 minutes of walking
or stationary cycling), combined with WL (- 500
to1000 kcal/day). Body composition was determined
by DXA and CT. IS was measured during euglycemia
hyperinsulinemia (40 mU•m-2•min-1),
and systemic energy expenditure and substrate
oxidation was determined via indirect calorimetry.
Fat mass and regional fat depots were significantly
reduced, with a mean WL of 9±1%, and VO2max
improved by 19%, from 38.8±1.2 to 46.0±1.0
ml´kgFFM-1´min-1 (p<0.05). IS improved
49±10% (6.70 ± 0.40 to 9.51 ±
0.51 mg•min-1•kg FFM-1; p<0.05).
Rates of FOX following an overnight fast increased
(1.16 ± 0.06 to 1.36 ± 0.05 mg•min-1•kg
FFM-1; p<0.05), and the proportion of energy
derived from FOX increased from 38% to 52%. In
a multivariate examination of factors associated
with improved IS, including changes in adiposity
and fitness, the strongest predictor was enhanced
fasting rates of FOX, accounting for 52% of the
variance in improvement of IS.
From the Results of the study it was conculed
that, in obesity, EX+WL substantially enhances
IS and increases post-absorptive FOX, and this
restoration of metabolic flexibility in skeletal
muscle is a key predictor of the improvement in
IS.
[1010-P] Improved Fat Oxidation Following Exercise
and Weight Loss (EX+WL) Predicts Improved Insulin
Sensitivity (IS) in Obesity BRET H. GOODPASTER,
CAROL A. KELLEY, ANDREAS KATSIARAS, DAVID E. KELLEY.
Pittsburgh, PA.
Increase fat oxidation by utilizing the 10,000
Step Program in your practice.
==============================
"Diabetes in
Control 10,000 Step Study 30 Million Steps and
15,000 Miles Later"
Because of the Diabetes In Control Study, more
than 3000 patients have started the Step Program.
Have a program for your office. Click
Here
.
