Early Tight Diabetes Control
Associated With Less Coronary Calcification
A continuing follow-up of the patients from the
DCCT cohort, showed that early intensive glycemic
control is associated with reduced coronary artery
calcification later on, even if glucose control
has subsequently become less intense over time.
That's according to long-term follow-up data from
the Epidemiology of Diabetes Interventions and
Complications (EDIC) study, a multicenter observational
study of 1150 type 1 diabetics from the original
DCCT cohort, presented during the American Diabetes
Association's 63rd Annual Scientific Sessions
in New Orleans.
Computed tomography of the coronary arteries seven
to nine years after the start of EDIC revealed
significantly less coronary calcification in those
in the intensive control vs. conventional control
arm of DCCT.
"Intensive control, bringing blood glucose
levels as close to normal as possible for an average
of 6-1/2 years, yielded reduced atherosclerosis
even after 8 years of less effective control,
compared to those who never achieved tight control,"
said Dr. John Lachin head of the DCCT/EDIC Coordinating
Center in an press statement.
In addition, the original intensive control group
has continued to show markedly less progression
of microvascular disease.
In comments at a press conference, the co-chair
of the DCCT/EDIC study Dr. David Nathan of Harvard
said: "Data are accumulating to support a
role of hyperglycemia in cardiovascular disease
in type 1 diabetes, similar to its role in the
pathogenesis of the microvascular complications.
The DCCT/EDIC study demonstrates a beneficial
effect of intensive therapy aimed at normalizing
long-term glucose control on coronary atherosclerosis."
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