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Item #8
Association
Between Autoimmune Thyroid Dysfunction And Type 1 Diabetes Confirmed
Study
confirms need for regular thyroid dysfunction screening.
Previous
cross-sectional studies have reported a two- to three-fold higher risk
of thyroid dysfunction in type 1 diabetics compared with the general
population, explain investigators. However, longitudinal studies have
been lacking.
The investigators, from the Divisions of Endocrinology and Preventive
Medicine at the University of Tennessee Health Science Center in
Memphis, United States, studied 26 men and 32 women who enrolled in
the centre's Diabetes Control and Complications Trial in 1983. The men
and women were prospectively followed for 18 years.
Results showed that 18 patients had hypothyroidism and 1 patient
experienced transient hyperthyroidism. Two subjects developed
hypothyroidism before diabetes and were excluded from the analysis.
Diabetes was diagnosed at a mean age of 19 ± 2 years and
hypothyroidism at 29 ± 3 years.
Forty-one percent of the female patients developed
hypothyroidism compared with 19% of the male patients.
Hypothyroidism was also more common in patients with thyroid
peroxidase antibodies. Patients who were positive for these antibodies
were 17.91 times as likely to develop hypothyroidism than their
negative counterparts.
The investigators suggest that patients with type 1 diabetes,
particularly those positive for thyroid peroxidase antibodies, should
undergo annual thyroid-stimulating hormone measurements to detect
asymptomatic thyroid dysfunction.
Diabetes
Care 2003;26:4:1181-1185
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