Item #7
Nasal
Metoclopramide Spray Useful in Treating Diabetic Gastroparesis
Nasal
metoclopramide may prove superior to oral tablets in treating diabetic
patients with symptomatic gastroparesis.
That,
according to research presented at the 2003 Annual Meeting of the
Society for Clinical Pharmacology and Therapeutics.
Dr.
Sian Bigora from GloboMax Service Group in Hanover, Maryland, and
associates compared the pharmacokinetics, efficacy, and safety of
metoclopramide nasal spray and orally administered metoclopramide
tablets in 89 patients with diabetic gastroparesis.
The
pharmacokinetics of the 20-mg spray did not differ significantly from
that of the 10-mg oral tablet, the results indicate, but the maximum
concentration (Cmax) was significantly lower with the 10-mg spray than
with the 10-mg oral tablet. There was generally greater variability in
the pharmacokinetics of the nasal formulation than that of the oral
tablets.
After
6 weeks of treatment, the mean improvements in total symptom scores
were significantly better after either 10-mg or 20-mg nasal spray
(16.8 and 18.0 points, respectively) than after 10-mg oral tablets
(14.3 points).
The
investigators concluded, "The results of this open label study
suggest that the metoclopramide nasal spray 10 mg and 20 mg may have
superior efficacy over the oral 10 mg tablets."
"Due
to the potential bias of this open label study," the researchers
added, "the efficacy results and conclusion need to be reproduced
and confirmed by further studies."
================================
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