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Item #11
Diabetes
Linked to Development of Alzheimer's Disease
People
with diabetes are at increased risk of going on to develop Alzheimer's
disease.
Dr.
Arvanitakis presented these findings here April 3rd at the
55th Annual Meeting of the American Academy of Neurology.
"We found that diabetes is associated both with a higher
likelihood of Alzheimer's disease and a greater rate of decline in
perceptual speed," said Dr. Arvanitakis, assistant professor,
Department of Neurological Sciences, Rush-Presbyterian-St. Luke's
Medical Center, Chicago, Illinois. This risk is independent of a
history of clinical stroke and whether or not an individual is a
carrier of apolipoprotein E (APOE).
She noted that few prospective studies have assessed diabetes as a
risk factor for either Alzheimer s disease or decline in cognitive
function. The existing studies have had variable results, she said.
Her study enrolled 869 older Catholic nuns, priests, and brothers who
were participants in the Religious Order Study. None of the subjects
had dementia at baseline. The subjects had detailed annual evaluations
for up to 8 years that included a clinical classification of dementia
and Alzheimer s disease, as well as cognitive function testing. From
these data, the investigators derived previously established summary
measures.
Among these subjects, 125 (14.4%) had diabetes. They were followed for
an average of 5.1 years. During this time, 141 subjects (16.2%)
developed Alzheimer s disease.
The investigators used a proportional hazards model adjusted for age,
sex, and education, which showed that people with diabetes had a 73%
greater chance of developing Alzheimer s disease compared to controls
(hazard ratio = 1.73, 95% CI: 1.15,2.61).
In a subsequent analysis the investigators controlled for age, sex,
and education, as well as baseline level of cognition. In this
analysis people with diabetes had a 51% greater rate of decline in
perceptual speed (P=0.01). However, this decline rate was not linked
to a rate of decline in either episodic memory or other cognitive
systems.
Study title:
Diabetes and Risk of Alzheimer s Disease and Change in Cognitive
Function. Abstract: S58.003
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DO
YOU KNOW
Composite
cardiovascular event rates are similar for conventional
antihypertensive treatment plus irbesartan, amlodipine or placebo in
patients with type 2 diabetic nephropathy and hypertension.
http://www.medscape.com/viewarticle/451914
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