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Item #5
Lack
of Vitamin D Increases Risk for Type 1 Diabetes
Vitamin
D-deficiency in infancy and vitamin D receptor gene polymorphisms
may be risk factors for insulin-dependent Diabetes.
The
biologically active form of vitamin D, is a potent modulator of
the immune system as well as a regulator of bone and mineral
metabolism.
"1,25(OH)2D3
and its analogs significantly repress the development of insulitis
and diabetes in the non-obese diabetic (NOD) mouse, a model of
human IDDM," reported Julia B. Zella and Hector F. DeLuca at
the University of Wisconsin-Madison.
They
continued, "1,25(OH)2D3 may modulate IDDM disease
pathogenesis by repression of type I cytokines, inhibition of
dendritic cell maturation, and upregulation of regulatory T cells.
The function of vitamin D as a genetic and environmental
determining factor for IDDM, the protective role of 1,25(OH)2D3
and its analogs in a mouse model of IDDM, and the possible
mechanisms by which this protection occurs will be reviewed."
Zella
and DeLuca published the results of their study in the Journal of
Cellular Biochemistry (Vitamin D and autoimmune diabetes. J
Cell Biochem, 2003;88(2):216-222).
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