Item #7
Metformin
Reduces Risk of Gestational Diabetes in PCOS
Treatment
with metformin appeared to cut the risk of gestational diabetes in a
study of 72 women with polycystic ovary syndrome.
The women together had a total of 76 pregnancies during which they
were treated with metformin; the incidence of gestational diabetes in
these pregnancies was 8%. In contrast, 39 other women with polycystic
ovary syndrome (PCOS) who were not diabetic and were not treated with
metformin but were managed at the same medical center had a 23%
incidence of gestational diabetes, Dr. Charles J. Glueck reported in a
poster at the annual scientific sessions of the American Heart
Association.
Prior reports have established that gestational diabetes occurs in
25%-45% of women with PCOS. In contrast, the risk of gestational
diabetes among the general U.S. population is 1%-4%, said Dr. Glueck,
medical director of the Cholesterol Center at Jewish Hospital,
Cincinnati.
The 72 women with PCOS but without diabetes began receiving metformin
at a daily dosage of 2.55 g before they conceived.
These women also adhered to a daily diet with 1,500 calories that was
high in protein (26% of calories) and low in carbohydrates (44% of
calories).
A total of 65 women continued to take metformin throughout the term of
their subsequent pregnancy. The drug was well tolerated and did not
appear to have an adverse effect on any of the children who were
delivered.
================================
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