|
Item
#6
Type
1 Diabetes Increases Stroke and Heart Disease Risk
The
risk of cardiovascular death for persons with Type I diabetes was more
than fivefold higher in men and sevenfold higher in women than in the
general population
The
risk that young people with Type I diabetes -- the kind in which the
body stops making insulin -- will die of stroke or other
cardiovascular disease is much higher than had been thought, a British
study finds.
In
the 20-to-39 age group, the risk of cardiovascular death for persons
with Type I diabetes was more than fivefold higher in men and
sevenfold higher in women than in the general population, says a
report in the February issue of Stroke.
This study was the
first to determine that type 1 diabetes is also a risk factor. The
effect is similar in all ages, and the magnitude of risk is at least
as great as with type 2 diabetes.
"The
results from this group of patients with type 1 diabetes show that at
all ages death from cerebrovascular disease is higher in the patients
with diabetes than in the general population," lead author Susan
P. Laing, PhD, from the Institute of Cancer Research in Surrey, U.K.,
says in a news release.
From
1972 to 1993, the Diabetes UK Cohort study identified 23,751 patients
diagnosed with type 1 diabetes before age 30 years, and it followed
them until December of 2000, for an average of 17 years.
Of
1,437 deaths, 80 were caused by cerebrovascular disease, which
accounted for 4% of all deaths younger than 40 years and 8% of all
deaths older than 40 years. Standardized mortality ratios (SMR) showed
that these rates were significantly higher than expected when compared
with the general population. SMR was 3.1 (95% confidence interval
[CI], 2.2 - 4.3) for men and 4.4 (95% CI, 3.1 - 6.0) for women.
In
subjects aged 20 to 39 years, the risk of cerebrovascular death was
increased more than five-fold in men and seven-fold in women compared
with the general population. Separate analysis of hemorrhagic and
nonhemorrhagic stroke still revealed a significant increase in
mortality from nonhemorrhagic stroke.
The
authors conclude that "at younger ages, the relative risks of
cerebrovascular mortality in patients with type 1 diabetes are very
high," and that at all ages they are "still comparable to
those of similarly aged patients with type 2 diabetes."
"These
observations emphasize the vital need to identify and treat known
cardiovascular risk factors in young people with diabetes," Dr.
Laing says. Stroke.
2003;34:000-000
===========================
DID
YOU KNOW:
Combination
therapy with alpha-glucosidase inhibitor and a SU agent prolongs the
duration of good glycemic control compared with SU alone in patients
with type 2 diabetes. Metabolism
2002 Dec;51(12):1548-52
|
