Item #12
Inflammation
Marker More Likely to Predict Diabetes in Women
C-reactive
protein (CRP) is an inflammation
marker that has been implicated
in the development of type 2 diabetes
in Caucasians.
However,
a new study has found that, among
Mexicans, CRP is likely to predict
type 2 diabetes in women but not
in men.
Researchers
in the United Kingdom,
Mexico and the United States who
evaluated 515 women and 729 men
from the Mexico City Diabetes Study report that, while CRP correlated
strongly with the metabolic syndrome
in women, the association was weaker in men.
The
metabolic syndrome includes two
or more of the following: blood lipid
disorder, defined as high triglycerides
or low HDL ("good") cholesterol; high
blood pressure; and diabetes.
At
the beginning of the study, none of the subjects had diabetes and
none had more than one of the metabolic
syndrome markers. After six
years, 14.2 percent of the men and 16 percent of the women had developed
the metabolic syndrome. Of
that group, 44.1 percent of the men
and 46.2 percent of the women had
developed diabetes. The incidence
of the metabolic syndrome adjusted
for age, smoking, alcohol use
and physical activity-was significantly
higher in women with higher levels
of CRP.
A
novel finding in this study is that
high levels of CRP in women predicted
metabolic syndrome even in the
absence of obesity and insulin resistance.
The
researchers note that most previous
studies on CRP and diabetes have not separated results for men
and women. Diabetes
Care, November 2002
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