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Item #8
Body
Fat Distribution Affects Insulin Level In Children
An
increase in subcutaneous abdominal fat appears to increase fasting
insulin levels in growing children, according to a report in Obesity
Research.
Terry
T. K. Huang and colleagues at the University of Southern California
and the University of Alabama at Birmingham measured fasting insulin
concentration, insulin sensitivity, and fat distribution in 77
children whose mean age at baseline was 8.3 years. Fasting insulin and
insulin sensitivity measures occurred at least three times each year
for 3 years.
A
significant association between fasting insulin level and increase in
visceral fat, independent of subcutaneous abdominal fat, was found.
For every 1 cm2/yr increase in visceral fat, fasting insulin increased
by approximately 5% (p<0.05).
A
similar relation existed between fasting insulin concentration and
subcutaneous abdominal fat, independent of visceral fat. For every 1
cm2/yr increase in subcutaneous abdominal fat, fasting insulin
increased by approximately 2% (p<0.02).
No
relation was found between an increase in fat and insulin sensitivity
(Effect of changes in fat distribution on the rates of change of
insulin response in children. "The rate of change in visceral fat
was positively associated with the rate of change in fasting insulin,
independent of increasing subcutaneous abdominal fat; however,
subcutaneous abdominal fat may be more predictive of the rate of
change of fasting insulin than visceral or total fat," concluded
Huang and associates. "Therefore, growth-related increases in
abdominal fat, particularly subcutaneous abdominal fat, may contribute
to accelerating increases in fasting insulin, but have no effect on
insulin sensitivity."
Key
points reported in this study include:
*
For every 1 cm2/year increase in visceral fat, an increase of 5% was
seen in fasting insulin concentration, independent of subcutaneous
abdominal fat
*
For every 1 cm2/year increase in subcutaneous abdominal fat, an
increase of 2% was seen in fasting insulin concentration, independent
of visceral fat
*
Insulin sensitivity did not correlate with amount of visceral or
subcutaneous abdominal fat in children
Obes
Res, 2002;10(10):978-984.
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