Item #12
Low
Heart Rate Variability Tied to Heart Disease in Diabetics
Impaired
heart rate variability is associated with an increased risk of
coronary heart disease (CHD) In type 2 diabetics.
The
data suggest that poor cardiac autonomic balance--which can be
assessed before clinical symptoms of neurological damage due to
elevated glucose levels--is related to higher risks of developing
coronary heart disease, especially among persons with type 2
diabetes". stated investigator Dr. Duanping Liao.
Dr.
Liao of Pennsylvania State University College of Medicine, Hershey,
and colleagues came to these conclusions following a prospective
cohort study of 11,654 people (aged 45 to 64 years at outset).
The
researchers used a variety of baseline cardiac parameters to determine
heart rate variability and thus cardiac autonomic control.
After
an average of 8 years of follow-up, 635 cases of CHD were identified.
In diabetics--comparing the lowest quartile of high frequency spectral
power with the remaining quartiles-the adjusted proportional hazard
ratio was 2.03 for myocardial infarction, 1.60 for incident CHD, 1.50
for fatal CHD and 1.27 for non-CHD death.
Analysis
using other cardiac parameters led to similar outcome patterns. In
non-diabetics, however, no consistent associations were identified.
They
concluded that at a population level, a lower heart rate variability,
which reflects impaired cardiac autonomic control, is statistically
significantly related to the development of CHD among individuals with
diabetes. Diabetes
2002;52:3524-3531.
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