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Item #8
Homocysteine
Elevates Blood Pressure
Studies
suggest that homocysteine may elevate blood pressure and
increase the risk of hypertension.
From
the Third National Health and Nutrition Examination Survey,
1988–1994
The
association of homocysteine with blood pressure and with
the risk of hypertension was investigated using
cross-sectional data from the Third National Health and Nutrition
Examination Survey (1998–1994).
Homocysteine
had an independent positive association with blood pressure
after adjusting for cardiovascular risk factors. A 1 standard
deviation (
 5
µmol/liter) increase in homocysteine was associated with
increases in diastolic and systolic blood pressure of 0.5
and 0.7 mmHg, respectively, in men and of 0.7 and 1.2 mmHg
in women. Similarly, higher levels of homocysteine were associated
with an increased risk of hypertension. In a comparison of
the highest and lowest quintiles of homocysteine, women had a
threefold increase in the risk of hypertension (95% confidence interval
(CI): 1.7, 5.4), and men had a twofold increase (95% CI:
0.7, 5.1).
In
light of the homocysteine-blood pressure association, the
association of homocysteine with prevalent cardiovascular disease
was examined with and without adjusting for blood pressure. The
results support a mediating role for blood pressure in women and
suggest that the full effect of homocysteine on cardiovascular risk
may be underestimated when blood pressure is adjusted
Am
J Epidemiol
2002; 156:1105-1113.
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