Insulin
Transport Delayed in The Obese
Obese
individuals have delayed transcapillary transport of insulin to muscle
tissue, 25 minutes slower, Swedish researchers report in the September
issue of Diabetes.
Dr.
Mikaela Sjostrand of Sahlgrenska University Hospital, Goteborg, and
colleagues note that insulin-resistant subjects have a slow onset of
insulin action. To determine whether delayed transcapillary action
might be involved, the researchers investigated the kinetics of
infused insulin and insulin in plasma and muscle interstitial fluid. A
total of 10 insulin-resistant obese subjects and 10 lean controls were
evaluated.
The obese subjects had a
significantly lower steady-state glucose infusion rate. They also
showed a delayed appearance of insulin. The time to reach half-maximal
plasma concentration was 72 minutes versus 46 minutes for controls. In
interstitial fluid, the corresponding figures were 83 versus 53
minutes.
Onset of insulin action
was 70 minutes in obese subjects and 45 minutes in controls.
Furthermore, the forearm blood flow rate in obese subjects was
significantly lower than that in controls.
Dr. Sjostrand feels that
"the impaired vasodilative effect of insulin may result in the
sluggish insulin transport to the muscle tissue in the obese group.
Therefore, it would be interesting to study the effect of vasodilating
agents on transcapillary insulin transport and muscle glucose uptake
in insulin resistant obese and type 2 diabetes subjects.
Diabetes
2002;51:2742-2748.
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