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Item #1

Experts Reach Consensus on Causes of Type 2 Diabetes

Genetics, fetal origins, lifestyle and stress may all be risk factors of Type 2 diabetes

Genetics, fetal history, lifestyle and stress may all favor the occurrence of Type 2 diabetes, according to experts at a recent meeting in Colombo, Sri Lanka. 350 international experts including representatives of the International Diabetes Federation (IDF) and the World Health Organization (WHO) met on 6-7 July under the banner of Diabetes in Asia 2002 to discuss the causes that could be at the origin of Type 2 diabetes. The subsequent consensus could help develop a primary prevention strategy to defuse the escalating incidence of this form of diabetes worldwide.

Type 2 diabetes is rising dramatically, with at least 170 million people with diabetes worldwide and a predicted increase to 300 million by 2025. More and more children and adolescents are developing Type 2 diabetes, a form of diabetes that used to be found mostly in adults. Up until now, scientists mainly focused on obesity due to lifestyle changes as being a cause of Type 2 diabetes, however, new studies reveal that genetics, fetal history and, possibly, stress may also play a role in the development of the condition.

Genetics was identified as a significant factor that causes diabetes. There is firm evidence from genetic studies that the association of some genes is at the root of causing Type 2 diabetes.

Low birth weight was recognized as another risk factor for Type 2 diabetes. Epidemiological studies have reported a higher incidence of Type 2 diabetes in people who had a low birth weight. Animal studies confirm that poor nourishment of the fetus increases the risk of metabolic syndrome and Type 2 diabetes. Furthermore, postnatal over-nutrition may aggravate the syndrome.

Obesity has long been associated with diabetes, Impaired Glucose Tolerance (IGT) and Cardiovascular Disease (CVD). Lifestyle changes, including bad eating habits and physical inactivity all contribute to obesity.

Finally, compelling animal evidence and mechanistic studies suggest a relationship between stress and insulin resistance leading to Type 2 diabetes.

"This consensus is likely to highlight the urgent need for the primary prevention of Type 2 diabetes." Said Professor Sir George Alberti, President of the IDF. "We hope that the consensus will facilitate the introduction of programs to increase awareness and promote education at all levels. There is urgent need for government action to promote healthy lifestyles now."    Read the Consensus Document.


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