History
of Type 2 Diabetes Delays Onset of Type 1 Diabetes
Results
of a study published in the July issue of The Journal of Clinical
Endocrinology and Metabolism indicate that a family history of type 2
diabetes delays the onset of type 1 diabetes.
Dr.
Sami T. Azar, of the American University of Beirut, in Lebanon, and
colleagues studied 253 patients with type 1 diabetes in relation to
HLA-DQB1 haplotype, gender, and early exposure to dairy products. They
also studied occurrence of the disease in relation to family history
of type 1 and type 2 diabetes.
"In
accordance with the reported literature," the patients had a
higher occurrence of the *0201 and *0302 alleles of HLA-DQB1, the
investigators report, and a much lower frequency of the protective
*0602 allele, compared with nondiabetic controls.
Dr.
Azar and colleagues observed no effect of early intake of cow's milk
on the age of onset of type 1 diabetes, and no gender preference.
However,
when they examined family history of diabetes, they found that a
history of type 2 diabetes was associated with a delay in the age of
onset of type 1 diabetes. Mean age at onset was 13 years in patients
with an immediate family history of type 2 diabetes, compared with 8
years in those with no such family history (p < 0.001).
"Studying
families with simultaneous presence of type 1 diabetes and type 2
diabetes may prove important in understanding the genetic
predisposition to type 1 diabetes as well as the genetic and
environmental factors involved in the onset of the disease," the
researchers suggest. J
Clin Endocrinol Metab 2002;87:3192-3196.
================================
Did
You Know?
Exercise
Reduces Diabetes Risk by Reducing Insulin Resistance
It has been shown numerous
times that exercise may prevent certain diseases such as heart disease
and diabetes, although the exact mechanism of this effect is often
disputed. This study found that one of these mechanisms is that
physical activity causes a reduction in insulin resistance.
·
The study included 5159 men aged 40 to 59 years with no
history of coronary heart disease, type 2 diabetes, or stroke.
·
During an average follow-up period of 16.8 years, there
were 616 cases of major coronary heart disease events (fatal and
nonfatal) and 196 incident cases of type 2 diabetes.
·
Physical activity was inversely related to coronary
heart disease rates, with the lowest rates in the men undertaking
moderate physical activity and with no further benefit thereafter.
The
authors maintain that insulin resistance definitely plays an important
role in the development of diabetes.
Archives of
Internal Medicine 2000;160:2108-2116.
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