|
[an error occurred while processing this directive]
|
Item #9
Diabetes
May Be Long-Term Risk Factor for Alzheimer's Disease-Another
Complication
Diabetes
diagnosis was still strongly associated with Alzheimer’s Disease
Diabetes
appears to be a long-term risk factor for Alzheimer's disease (AD) and
this risk is not associated with insulin therapy, suggest the results
of a 35-year longitudinal study of Israeli men.
The research was presented July 23 at the 8th International
Conference on Alzheimer's Disease and Related Disorders.
Ramit Ravona-Springer, MD, of Sheba Medical Center, Tel-Hashomer, in
Ramat Gan, Israel, and colleagues followed Israeli men who were 40
years or older and were participants in a 1963 cardiovascular risk
factor cohort study. The men were assessed for diagnosis of dementia
in 1999.
The researchers studied 2903 men who were alive in 1999 from the
original cardiovascular risk factor cohort of 10,059 men. They
assessed the presence of dementia in 1887 subjects, of whom 253 had AD
and 1403 had no cognitive impairment. They excluded those with other
dementias or mild cognitive impairment.
Among survivors who had diabetes (45 men) 13 (30.2 percent) were
diagnosed with AD at follow-up, compared to 15.1 percent of all
subjects in the analysis. In a logistic regression analysis, after
controlling for age, diabetes diagnosis was strongly associated with
AD.
Of 11 men with diabetes who were on hypoglycemic/insulin therapy,
three had AD (27.3 percent). In a logistic regression analysis, after
controlling for age and hypoglycemic/insulin therapy, diabetes
diagnosis was still strongly associated with AD
[an error occurred while processing this directive]
|
[an error occurred while processing this directive]
|
