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DIABETES IN CONTROL
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Kristina
Sandstedt, MS
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 Kristina
Sandstedt,
MS,
Clinical
Exercise
Physiologist,
Diabetes
Educator
“The
Role
of
Exercise
in
the
Treatment
of
Arthritis”,
Why
this
information
is
important
for
Diabetes
Educators
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Evan
D.
Rosen,
M.D.,
Ph.D
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Dr.
Evan
Rosen
 Winning
the
Battle,
but
Losing
the
War
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Shafer
Monthly Feature
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 “ANTIOXIDANTS”
Antioxidants
have
received
a
lot
of
attention
in
recent
years,
in
relation
to
wellness
and
disease
prevention.
More
studies
are
needed
to
better
understand
how
antioxidants
may
affect
diabetes
management
and
treatment.
Click
Here
By Sherri Shafer,
R.D., CDE,
View
Sherri's Archives
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NOMINATE YOUR
CHOICE
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Best
Diabetes
Product
or
Service
of
the
New
Millennium
Medical
Professionals
CHOICE
AWARD
CLICK
HERE
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Dr. Eric S. Freedland
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 Dr.
Eric Freedland
continues his series
Why
Focusing On Intensive Glucose Control With Drugs Alone Is
Counterproductive with
Part
10
Manipulating
Macronutrient
Ratios
Eric S. Freedland, MD
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PRINT
THE NEWSLETTER
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Print this weeks Newsletter Here.
Adobe
format
22
pages
Download
Adobe format
click here.
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Dr.
Thomas Burke Ph.D
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-
 Dr
Thomas Burke brings
us a wound care case study by Alan
Kochman, PT, MS and Diane
Pogmore, RN, CWOCN
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SUBSCRIBE |
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Item #17
Anti-Inflammatory
Effect of Rosiglitazone in Obese Diabetic Patients
Rosiglitazone
exerts an anti-inflammatory effect at the cellular and molecular
level.
We
have recently demonstrated a potent anti-inflammatory effect of
rosiglitazone (RSG) in obese non-diabetic subjects. We have now
investigated the anti-inflammatory action in 11 obese diabetes
patients who were given RSG 4 mg/day for 6 weeks. Fasting blood
samples were obtained at 0, 1, 2, 4, 6 and 12 weeks.
Blood
glucose concentration decreased significantly following RSG treatment,
from a basal concentration of 157 ± 16 mg/dL to 127 ± 9 mg/dL at
week 6 (p<0.05). Insulin concentration also significantly decreased
from a basal concentration of 32.6 ± 4.6 mU/mL to 16.1 ± 2.2 mU/mL
at week 6 (p<0.05). NF-kB binding activity in MNC nuclear extract
fell significantly (p<0.02). This inhibition was significant by
week 1 (77 ± 13% of the basal level) and continued up to week 6 (66
± 10.6% of basal). There was a significant fall in ROS generation by
MNC (p<0.05), decreasing to 94 ± 6% by week 1 and 66 ± 10% at
week 6. RSG treatment reduced plasma MCP-1 (75% of the basal level;
p<0.05) and CRP (70% of basal; p<0.05). FMD at baseline was 3.4
± 1.2% and this increased significantly to 8.6 ± 1.9% (p<0.05) at
week 6. Nitroglycerin-induced endothelium independent vasodilatation
also increased from 11.8 ± 1.4% at baseline to 16.7 ± 2.3% at week 6
(p<0.05).
We
conclude that RSG exerts a profound ROS suppressive and
anti-inflammatory effect as reflected at the cellular and molecular
level, and in plasma. RSG also improves vascular reactivity. These
observations may have implications for atherogenesis in the long-term
in patients treated with RSG.
Endo
2002 [P2-376]
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DIABETES NEWS FLASH
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Dr.
Jennifer Larson
Feature
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Dr
Jennifer Larson, MD,
University
of Nebraska Medical Center, gave
a very informative overview of Pancreas,
Islet, and Kidney Transplantation: Metabolic and Endocrine
Consequences, at the Endo2002 conference. We have an overview
of her presentation, click
here
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TOP
DIABETES STORIES
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New
Drug Restores Eyesight*
Click
Here
Diabetes
Management Market Predicted to Explode*
Click
Here
Night-Light
May Prevent Diabetic Eye Damage*
Click
Here
New
Test Predicts Which Type 2’s Will Become Type 1’s Within 5 Years*
Click
Here
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FREE
WEBSITE!!!
|
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Get
a
FREE
website
for
your
Diabetes
Organization.
Click
Here
To
Learn
More
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NEW PRODUCT
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|
 400
needles
that
pierce
the
skin
and
let
big
molecules
enter
the
bloodstream.
Drug
delivery
with
this
techniques
offers
several
advantages
over
pills
and
injections.
It
can
ensure
the
steady
release
of
medication
into
the
patient's
bloodstream
over
long
periods,
improving
the
efficacy
of a
dose.
It
can
prevent
the
rapid
breakdown
that
many
drugs
taken
orally
undergo
when
they
pass
through
the
digestive
system.
Click
here
for
more
information:
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Dr Richard K. Bernstein
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This
Months Corner:
 Dr.
Bernstein's
Feature:
Will
eating a low-fat
diet help you
live longer?
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INSIDE
DIABETES
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David
Kliff
 The
Pump Market - A
Market in
Turmoil
ADA
Highlights
David
Kliff, Publisher
The Diabetic Investor
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In
2 Nutrition
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Generate
Individualized meal plans for your patients!
See how your
patients can receive over 250 personalized recipes that are ideal
for individuals with diabetes, high cholesterol, heart disease and
weight management problems.
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NEWS
FLASH
!!!
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Over
One
million
US
adults
can't
afford
their
drugs
Click
Here
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FREE
CME!
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Free
CME
The
Hyperactive
Platelet
in
Type
2
Diabetes-
sponsored
by
Baylor
College
of
Medicine,
Houston,
Texas,
offers
2
hours
of
AMA
PRA
category
1
credit
To
access
this
free
on-line
activity,
visit
Click
Here
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