|
[an error occurred while processing this directive]
|
Item #7
AACE:
Combination Therapy Best For Diabetics With Higher Glycemic Levels
First
line treatment of glyburide and metformin found to be safe and
effective with synergistic results.
A
combination of glyburide and metformin are effective and safe as
first-line therapy in patients with inadequately controlled type 2
diabetes, researchers reported here today at the annual meeting of the
American Association of Clinical Endocrinologists.
Also, combination treatment with glyburide/metformin (G/M) 1.25/250 mg
demonstrated clinical usefulness in patients with poor baseline
control, the researchers said.
For the 16-week, double-blind, researchers led by A. J. Garber, MD,
professor of medicine at Baylor University College of Medicine, in
Houston, Texas, enrolled 486 drug naive subjects, 20 to 78 years of
age, with body mass index in the range of 23-40 kg/m˛.
Patients were randomized to receive glyburide 2.5 mg, metformin 500
mg, or G/M 1.25/250 mg. Investigators titrated doses for patients with
mean daily glucose 126 mg/dL or higher.
Primary end point was change in hemoglobin A1c (HbA1c) values at week
16.
Mean final doses were: 7.6 mg for glyburide monotherapy, 1796 mg for
metformin monotherapy, and 3.7/735 mg for G/M.
G/M reduced HbA1c from baseline by 2.3 percent compared to reductions
of 1.9 percent with glyburide and 1.5 percent with metformin (p=0.0003
for superiority of G/M over monotherapy). For patients with HbA1c
levels of 12 percent or higher, G/M resulted in better glycemic
control than the use of either agent as a monotherapy.
The authors noted that, in a previous trial, G/M showed superior
glycemic control when compared to glyburide and metformin monotherapy.
However, they said, "This study is unique because it includes
patients with higher baseline HbA1c values."
(The study was sponsored by
Bristol-Myers Squibb.)
Advertisement
Diabetes
Cannot Wait! Not Even 8
Minutes!
The
First Instant Disposable HbA1c Test is Now Available for Home and
Office and is NGSP Certified.
Know
your number TODAY! And prevent the complications from diabetes
TOMORROW!
If
you are not using an A1c test, which is now NGSP
certified, that gives results while the patient is in front of
you, you are missing a great opportunity to motivate. The A1cNow test
is now available for shipping. You
can now have your patients check their HbA1c when they come in for
their appointments.
Studies
have shown that by having the results when you consul your patient,
that you will have better compliance and more positive results. For a
special price go to www.A1cNow.net
[an error occurred while processing this directive]
|
[an error occurred while processing this directive]
|
