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Item #3
Impaired
Glucose Tolerance is a More Advanced Stage of Alteration in the
Glucose Metabolism than Impaired Fasting Glucose
Recent
reports have shown a lack of agreement between the impaired
glucose tolerance (IGT) and the impaired fasting glucose (IFG)
categories, suggesting that correspond to different impaired
glucose metabolism stages.
The
purpose of the study was to determine the differences of serum
insulin levels between subjects with IFG and IGT diagnoses.
Methods: Cross-sectional study of 52 subjects with IFG and 48 with
IGT diagnosis, and a euglycemic group of 140 subjects. Serum
glucose and insulin were measured in both fasting and 2-h 75-g
oral post-load glucose (2-h PG).
Results:
Subjects with IFG showed the highest fasting and 2-h PG serum
insulin levels, whereas subject with IGT the lowest. Serum insulin
values showed no significative changes between the fasting and 2-h
PG conditions in the subjects with IGT, whereas the subjects with
IFG showed significative hyperinsulinemia. The serum glucose 2-h
PG showed an increase of 0.2 mmol/l (CI95% 0.07-0.33), 0.5 mmol/l
(CI95% 0.41-0.58) and 3.6 mmol/l (CI95% 3.39-3.81) with respect to
basal values, whereas the increase of serum insulin 2-h PG was of
54 pmol/l (CI95% 53.71-55.29), 918 pmol/l (CI95% 917.49-918.51)
and 0.5 pmol/l (CI95% 0.15-0.84) for the euglycemic, IFG and IGT
subjects, respectively.
Conclusions:
This study demonstrates that subjects with IFG show
hyperinsulinemia whereas those with IGT have low insulin secretion
in response to oral load glucose, suggesting that IFG and IGT
correspond to different stages of impaired glucose metabolism.
Journal
of Diabetes and its Complications
2001 15/1 (34-37)
FACT:
In
a recent study, the caffeine consumed in 5 cups of coffee daily
caused a mild increase in blood pressure in elderly people who
already had hypertension, but not in those who had normal blood
pressures. What's more, the combination of smoking and drinking
coffee in persons with high blood pressure may increase the blood
pressure more than coffee alone. Limiting caffeine intake and
cigarette smoking in hypertensive individuals, therefore, may be
of some benefit in controlling their high blood pressure.
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