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Item #10
Autonomic
Function Tests Not Affected by Obesity in Diabetic Patients
Researchers
found no difference on autonomic function tests among normal
weight, overweight, obese, and morbidly obese patients with type 1
or type 2 diabetes
Obesity
is not a confounding factor in testing diabetes mellitus patients
for cardiovascular autonomic dysfunction, and does not effect the
reproducibility of autonomic function tests.
Those tests are important for both the obese and non-obese because
of the association of reduced respiratory rates (RR)-variation
with intolerance to exercise, intraoperative cardiovascular
lability and increased risk of death say Raelene E. Maser, PhD,
and a colleague at the Christiana Care Health Services, Newark,
Delaware, United States.
Researchers found no difference on autonomic function tests among
normal weight, overweight, obese, and morbidly obese patients with
type 1 or type 2 diabetes. Normal weight was defined as a body
mass index (BMI) of 25kg/m˛ or less; overweight was defined as
BMI of 25.01-30kg/m˛; obese was defined as BMI of 30.01-40kg/m˛;
and morbidly obese was defined as BMI 40.1kg/m˛ or greater.
One hundred and fifty-nine patients took part in this
cross-sectional study which used autonomic function tests,
including RR-variation during deep breathing and the Valsalva
ratio. The ANS2000 ECG Monitor and Respiration Pacer were used to
assess these tests and vector analysis (i.e. mean circular
resultant, MCR) was used to measure RR-variation.
Assessment of the reproducibility of the autonomic function tests
was made by determining the coefficient of variation (CV) on
repeat testing.
Diabetes,
Obesity and Metabolism, March 2002, 4 (2);113-117.
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