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Item #8.
Moderate
Aerobic Exercise Has Little Effect On Insulin Sensitivity
Three
months of moderate aerobic exercise did not improve insulin
sensitivity in obese men with type 2 diabetes taking oral
hypoglycemic agents.
However,
non-obese diabetics did show increased insulin sensitivity with
exercise.
The study was conducted by investigators at the Quebec Heart
Institute at Laval Hospital in Quebec City, Quebec, Canada. Six
non-obese and seven obese men with type 2 diabetes treated with
oral hypoglycemic agents participated in a 12-week ergocycle
program at 60 percent VO2 peak for one hour a day, three times a
week. Diet and medication were unchanged during the study. The
investigators assessed insulin sensitivity using the euglycemic
hyperinsulinemic clamp technique.
Aerobic exercise did result in an increased VO2 peak during the
12-week period. Considered as a single group, the patients showed
no significant changes in fat mass, percent body fat, fasting
plasma glucose and insulin levels, glycated hemoglobin levels or
insulin sensitivity.
When investigators divided the patients into obese and non-obese
groups, they found that only non-obese patients showed increased
insulin sensitivity. No change was observed in the obese patients.
The investigators conclude that adiposity may be a determining
factor in the metabolic benefits of exercise training in patients
with type 2 diabetes.
Med Sci Monit 2002; 8(2): CR59-65
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Did
You Know:
Results
of a large U.S. nationwide study released in August 2001 showed
that people with impaired glucose tolerance can reduce their risk
of type 2 diabetes by 58% with an intensive lifestyle modification
program that results in modest, sustained weight loss and about 30
minutes per day of moderate exercise. A medication, metformin, was
shown to decrease diabetes risk in people with impaired glucose
tolerance by 31%.
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