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Item
#3
Nateglinide
+ Metformin = 1.4% Decrease in A1c
This
published results are from last year, but still very few patients
have been put on the combination
The
combination of the investigational drug nateglinide with metformin
has been shown to help control blood glucose levels among subjects
with type 2 diabetes.
Study
data showed that when nateglinide was combined with metformin,
glycosylated hemoglobin A (HbA1c) levels decreased by 1.4% from
baseline. Nateglinide monotherapy decreased HbA1c levels by 0.5%
from baseline, while metformin alone decreased subjects' HbA1c by
0.8%, the researchers said.
"What
nateglinide does is
restore the first phase of insulin secretion, which is lost in
people with type 2 diabetes.
In the study of 685 patients with type 2 diabetes,
nateglinide reduced mealtime glucose spikes by increasing early
phase insulin secretion. Metformin reduced fasting plasma glucose
levels by reducing glucose production, and thereby improved
insulin sensitivity.
When
taken before a meal, nateglinide kicks out insulin very quickly,
so blood sugar levels don't jump up abruptly. When nateglinide was
taken with metformin, the combination of agents lowered the risk
of postprandial hypoglycemia.
Subjects
in the 24-week, randomized, double-blind, placebo-controlled study
were given nateglinide (120 mg before three meals) in comparison
or in combination with metformin (500 mg with three meals).
Fasting plasma glucose levels decreased 0.7 mM with nateglinide,
1.6 mM with metformin and 2.4 mM with the combination of the two
agents, compared with baseline.
Nateglinide,
"represents a new class of drugs that stimulate insulin
release from the pancreas at mealtimes, Is now available from
Novartis as Starlix® Glucophage
(metformin) is now available as a generic version for a 70%
savings.
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FACT:
In
The next ten years, over two million people will die from diabetes
and over one trillion will be lost in direct and indirect costs
due to diabetes.
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