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Item
#2
Pioglitazone
Controls Glycemia And Increases Body Mass Index
Pioglitazone
controls glycemia and blood pressure, despite increasing body mass
index and subcutaneous adipose tissue area in patients with type 2
diabetes.
Researchers from Keio University School of Medicine, Tokyo and
other Japanese centres, including the Chugai Diagnostics Science
Company, enrolled 10 male type II diabetics, aged between 40 and
66 years. Seven were treated with diet alone, while three took a
stable dose of sulfonylurea. All received pioglitazone 30 mg daily
for three months.
After treatment, mean blood pressure fell by 8 mmHg compared to
baseline. Fasting plasma glucose declined by 1.6 mmol/L, serum
insulin fell by 24 pmol/L and HbA1c reduced by 0.6
percent by the end of pioglitazone treatment. At the same time,
body mass index rose by 0.6 kg/m² and low-density lipoprotein
(LDL) cholesterol increased by 14 mg/dL. Moreover, subcutaneous
adipose tissue area and serum adiponectin concentrations increased
by 24 cm² and 9.6 µg/ml respectively.
Concentrations of neither triglycerides nor high-density
lipoprotein (HDL) cholesterol changed significantly. Visceral
adipose tissue area increased by 15 cm². The ratio of visceral
adipose tissue area to subcutaneous adipose tissue area declined
by 0.1. However, neither of the latter two differences was
statistically significant.
The authors concluded that pioglitazone controls glycemia and
blood pressure, despite increasing body mass index and
subcutaneous adipose tissue area in Japanese men with type 2
diabetes. The authors added that as pioglitazone increases serum
adiponectin level, it might counter atherosclerosis. Metabolism
2002;51:314-7
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FACT:
Recent
studies show that the health care expenditures are as much as five
times higher for individuals with diabetes compared to individuals
without diabetes
If
your patients are having a problem paying for their medications go
to www.diabetesmeds.org
and download the application that will allow them to get all of
their medications for 10 dollars or less for a 90 day supply.
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