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Item
#10
Inflammatory
Marker Predicts Type 2 Diabetes Risk
Researchers
have identified chronic inflammation as a new risk factor for
developing type 2 diabetes.
In
particular plasminogen activator inhibitor-1 (PAI-1), as an
independent predictor of type 2 diabetes.
Writing
in the April issue of Diabetes, Dr. Steven M. Haffner, from The
University of Texas Health Science Center at San Antonio, and
colleagues collected data on 1047 nondiabetics who participated in
the Insulin Resistance Atherosclerosis Study. In this population,
the researchers measured baseline C-reactive protein, fibrinogen,
and PAI-1 concentrations.
During
5 years of follow-up, 144 subjects developed type 2 diabetes.
Compared with nondiabetics, subjects who developed type 2 diabetes
had higher baseline fibrinogen levels (mean 275.1 mg/dL versus
287.8 mg/dL.) Concentrations of C-reactive protein were also
higher in diabetics (median 2.40 mg/L) compared with nondiabetics,
the researchers found.
Baseline
PAI-1 concentrations were also higher in patients who developed
type 2 diabetes compared with nondiabetics (24 ng/mL versus 16
ng/mL), Dr. Haffner's group adds.
When
the investigators adjusted the data to take into account body fat
and insulin sensitivity the association between diabetes and
fibrinogen and C-reactive protein was significantly attenuated,
while the association with PAI-1 did not diminish.
Regression
analysis that adjusted for age, sex, ethnicity, clinical center,
smoking, body mass index, insulin sensitivity, physical activity,
and family history of diabetes, showed that PAI-1 remained a
significant factor in the incidence of type 2 diabetes (odds ratio
1.61, p = 0.0017).
Dr.
Haffner and colleagues conclude that "high PAI-1 levels in
subjects with normal glucose tolerance may help to identify a
high-risk population with the potential to prevent both
atherosclerotic disease and type 2 diabetes, two major causes of
premature morbidity and morality, by targeting its common
antecedent." Diabetes
2002;51:1131-1137.
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Did
you know?
How
you can explain in plain English the importance of the A1c test
and what it means?
Click
on the link below to print out a feature that explains it to the
patient. (Requires Acrobat Reader)
Patients
Results
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