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Issue 130 Item 14 Markers of Inflammation are Strong Predictors of Heart Attacks

May 6, 2002

Available data suggest that low-grade chronic inflammation not only reflects the underlying macrovascular disease but is also actively involved in the initial and advanced status of atherogenesis. In a population at risk for type 2 diabetes it has been demonstrated that subclinical inflammation also underlies the metabolic syndrome through association of one of its primary anomalies, insulin resistance. No association was found between subclinical inflammation and impaired insulin secretion

Subclinical inflammation is strongly related to insulin resistance but not to impaired insulin secretion in a high risk population for diabetes

Subclinical inflammation was shown to be a strong predictor of cardiovascular events and was suggested to be a part of the metabolic syndrome (MS). The aim of the present study was to investigate the relationship of the inflammatory parameters-leukocyte count, C-reactive protein (CRP), and fibrinogen level -to insulin resistance and insulin secretion, as well as to other components of the MS in a population at risk for diabetes.

A total of 396 subjects (142 men and 254 women) were analyzed from the follow-up of the Risk Factors in Impaired Glucose tolerance (IGT) for Atherosclerosis and Diabetes (RIAD) study, who were at risk for type 2 diabetes, such as family history of diabetes, obesity, and/or hyper/dyslipoproteinemia.

A variety of risk factors within the MS were examined: lipids, glycemic parameters, coagulation, insulin fractions. and microalbuminuria.

Thus, in a population at risk for type 2 diabetes we demonstrate that subclinical inflammation underlies the metabolic syndrome, through association to one of its primary anomalies- insulin resistance, whereas no association was found to impaired insulin secretion. Metabolism: Clinical and Experimental 2002 51/6 (743-749)