Among patients with diabetes, those with diabetic retinopathy had elevated stroke risk compared with those who did not, according to new data from the ACCORD Eye study presented at the International Stroke Conference. The findings, based on 2,828 patients with diabetes, showed that 41% of those who had a stroke during a mean follow-up of 5.4 years had diabetic retinopathy, while 30.5% of those who didn’t have stroke had diabetic retinopathy.  After adjustment for age, sex, race, total cholesterol, HbA1c, smoking, and randomization arm, diabetic retinopathy remained associated with stroke incidence (HR = 1.6; 95% CI, 1.1-2.32).  The results were consistent regardless of randomization to intensive or standard glucose control (P = .305), intensive or standard lipid control (P = .546), or intensive or standard BP control (P = .422), according to the researchers.  While the pathology of this association is not clear, the shared vascular risk factors suggest damage to a range of arteries results from uncontrolled hyperglycemia, hypertension, and hyperlipidemia, 

Wong KH, et al. Abstract 154. Presented at: International Stroke Conference; Feb. 19-21, 2020; Los Angeles.