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Insulin and Glucagon Co-administration – Optimizing Glycemic Control without Risks of Hypoglycemia

Aug 29, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Melinda Rodriguez, PharmD Candidate 2021, Lake Erie College of Osteopathic Medicine – L|E|C|O|M School of Pharmacy

Opposing actions of insulin and glucagon may be the key to glucose control. 

The risk of hypoglycemia is of enormous concern among people with diabetes on insulin-containing regimens. These risks are even higher in those taking beta-blockers, as symptoms of low blood sugar can be masked by the drug. People of older age showing cognitive decline are also at higher risk and may not notice life-threatening drops in glucose levels when they occur. Considerable effort is required by both the patient and provider to manage and coordinate diet, activity, insulin administration, and blood glucose monitoring. Despite advancements in medicine and technology, the risk of hypoglycemia remains a significant obstacle in diabetes management....

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