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A 48-year-old woman who has had Type 2 diabetes mellitus for several years is seen for a routine follow-up evaluation. Her metabolic control has always been very good, with most hemoglobin A1c values less than 6.5%. Her current treatment is metformin 850 mg twice daily. She self-monitors her blood glucose two to three times daily and usually checks random 2-hour postprandial glucose values at least once daily. She notes that her postprandial glucose levels have been above her target of less than 160 mg/dL (8.88 mmol/L) for several weeks, despite increasing her activity level by walking three or four times weekly after dinner.
Her body mass index is 29.2. Her blood pressure is 128/86 mm Hg, and her A1c value is 7.2%. Self-monitored blood glucose values from the past week are noted in her log as follows:
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BLOOD GLUCOSE VALUE, mg/dL
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Breakfast
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Lunch
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Dinner
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Day
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Pre
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Post
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Pre
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Post
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Pre
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Post
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Bedtime
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Comments
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Sun
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96
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109
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132
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—
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—
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—
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Ate pastry
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Mon
|
114
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207
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—
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—
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97
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178
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—
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Walked
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Tue
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—
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—
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—
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—
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136
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217
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—
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—
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Wed
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91
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235
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—
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99
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83
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—
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—
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Walked
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Thu
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89
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—
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121
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118
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—
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261
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—
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—
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Fri
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76
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—
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—
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—
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78
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188
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—
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Walked
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Sat
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79
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194
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—
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—
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148
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—
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—
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—
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Pre = preprandial; post = 2-hour postprandial.
QUESTION:
Which of the following is the most appropriate change to this patient's treatment regimen?
A. Increase metformin to 1000 mg twice daily.
B. Initiate preprandial fast-acting insulin on nonexercise days.
C. Add glargine at bedtime.
D. Add a short-acting secretagogue (either repaglinide or nateglinide).
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