The paclitaxel-eluting stent had a non-significant lower incidence of target vessel revascularization and major adverse events compared with sirolimus-eluting stent in non-insulin-dependent diabetics at 2 years. The rate of adverse events was higher with sirolimus-eluting stent at 1 year.

The 2-year cumulative mortality was comparable in all three groups. However, mortality rate during the second year was 5.8% in the sirolimus-eluting stent group compared with 1.2% in the paclitaxel-eluting stent group (p = 0.007).

The investigators observed that the incidence of stent thrombosis was 4.4% in the sirolimus-eluting stent group compared with 2.4% in the paclitaxel-eluting stent group and 0.8% in patients who received bare metal stents. The higher mortality rate with sirolimus-eluting stent may be related to the increased incidence of stent thrombosis in patients treated with the sirolimus-eluting stent.

The Dutch team notes that, overall, "there was no significant difference between sirolimus-eluting stent and paclitaxel-eluting stent in each of the clinical endpoints, and neither in the non-insulin-dependent diabetes mellitus group, which are hypothesized to be better off with paclitaxel-eluting stent."

"The present study suffers from the inherent limitations of a non-randomized trial," Dr. Serruys' team notes. "More larger-scale and randomized trials are needed to elucidate the best treatment for patients with diabetes mellitus and the possible superiority of one drug-eluting stent compared to another, also taking into account the long-term adverse events like stent thrombosis," the Dutch investigators conclude.

As reported in the January issue of the European Heart Journal. However, the question of whether one drug-eluting stent is superior to the other remains unclear.

Eur Heart J 2007;28:26-32.

================================

Start your own walking program
New StepTracker Available at special prices. See the results of the Step Program Study.
http://www.diabetesincontrol.com/programs/steps/index.shtml
Purchase your own pedometers and receive the Steps to Health Program at no charge. http://www.rx4betterhealth.com/steptracker/
The Only Pedometer on the Market That Comes With a Program for Success!

================================

DID YOU KNOW:
What Prevents Doctors from Counseling Their Patients to Lose Weight, Exercise, Quit Smoking?: Ninety-nine percent of doctors believe that part of their job is to encourage their patients to live a healthier lifestyle, but only 20% actually do it. Research at the University of Haifa addresses the question: why not? See this week’s Item #6