This week we would like you to answer the question:

Which of the following does not describe the mechanism by which the incretin GLP-1 activates pathways to benefit the beta cell?

1. It lowers blood glucose and lowers free fatty acids

2. It modulates insulin secretion by stimulating the sulfonylurea

3. It improves the metabolic environment outside the beta cell

4. Its receptor is expressed directly on the beta cell

5. It is coupled to pathways that stimulate mitogenesis, as well as to pathways important for cell survival