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This article originally posted 30 November, 2004 and appeared in Issue 236

CRP Levels Predict Type 1 Diabetes

Patients with diabetes suffered significantly greater dyslipidemia and activated hemostasis and inflammation than those without diabetes.

Elevated C-reactive protein (CRP) is a marker of inflammation. Elevated CRP has also been observed in people with type 2 diabetes, gestational diabetes, and the metabolic syndrome.

Researchers, curious whether elevated CRP levels might also predict the development of type 1 diabetes in children, performed a subanalysis of children enrolled in the Diabetes Autoimmunity Study of the Young (DAISY), and found that it just might. They suggest that future studies in diabetes prevention consider the use of anti-inflammatory agents.

In a study of 4,066 British men aged 60-79 years, researchers identified 467 men with prevalent diabetes and 842 with prevalent coronary heart disease.

Concentrating on unconventional risk factors, researchers found that patients with diabetes suffered significantly greater dyslipidaemia and activated haemostasis and inflammation than those without diabetes. This finding was even more apparent in those with no history of coronary heart disease.

It remains to be seen whether reducing insulin resistance by non-pharmacological or pharmacological therapy reduces activation of haemostasis and inflammation.

Diabetes,53 (2569-2573): Elevated C-reactive protein levels in the development of type 1 diabetes

Diabetologia,47 (1557-1565 Insulin resistance, haemostatic and inflammatory markers and coronary heart disease risk factors in Type 2 diabetic men with and without coronary heart disease

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