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This article originally posted and appeared in  MedicationBG ControlType 1 DiabetesInsulinIssue 670

Novo Nordisk Creates Insulin Pill

Insulin tablets' safety, tolerability, exposure, and effect on blood glucose levels were tested in a clinical trial....


Novo Nordisk, in conjunction with Danish manufacturer Merrion Pharmaceuticals Plc., have tested oral insulin and successfully completed early stages trials. Currently, insulin is only available by injection for patients who do not produce enough insulin or are resistant to insulin. The insulin pill, known as NN1954, uses Glipet technology that allows them to make tablets/capsules of drugs that could only otherwise be given by injection1. "GIPET uses specifically designed oral formulations of patented absorption enhancers which activate micelle formation, facilitating transport of drug and substantially increasing absorption, with good reproducibility and a strong safety profile." 2

Novo Nordisk completed the first of three phases of testing that included safety, tolerability, exposure, and effect on glucose levels. The trial had 83 participants from May to October 2012. The results of the trial are not available yet and are expected to be available in the future. Novo Nordisk's oral insulin will be ground breaking technology that will give patients another option besides injection. In the future, it may enhance diabetes care and optimize blood glucose levels in patients that refuse insulin because of limited dosage forms1.



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This article originally posted 28 March, 2013 and appeared in  MedicationBG ControlType 1 DiabetesInsulinIssue 670

Past five issues: Diabetes Clinical Mastery Series Issue 255 | Issue 795 | SGLT-2 Inhibitors Special Edition August 2015 | Diabetes Clinical Mastery Series Issue 254 | GLP-1 Special Editions August 2015 |

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Lynn Grieger, CDE, RD

Category: Nutrition
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