Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted and appeared in  OncologyIssue 669

Incretin Mimetics and Risk of Pancreatic Cancer?

FDA has launched an investigation on an unpublished study suggesting that incretin mimetics are associated with pancreatic cancer.... 

Advertisement

The US Food and Drug Administration (FDA) is evaluating an increased risk for pancreatitis and precancerous cellular changes called pancreatic-duct metaplasia associated with incretin mimetic drugs used to treat patients with type 2 diabetes. This covers the glucagon-like peptide-1 (GLP-1) agonists and the DPP-4 inhibitors, both relatively new classes of agent used to treat adults with type 2 diabetes. A group of researchers came up with a study showing that there is a link between incretin mimetics and pancreatic cancer.

In the unpublished study, researchers examined a small number of pancreatic tissue specimens taken from patients after they died from unspecific cause. FDA requested the researchers to provide the methodology of the study as well as the tissue samples for further investigation.

Incretin mimetic drugs work by mimicking the incretin hormones that are naturally produced to stimulate secretion of insulin in response to a meal. It was known that these agents might increase risk of acute pancreatitis.

This is the first time FDA has issued a communication with regard to the potential risk for precancerous findings of the pancreas with incretin mimetics. It emphasizes, however, that it "has not concluded these drugs may cause or contribute to the development of pancreatic cancer."

According to study leader Dr. Sonal Singh, M.D., M.P.H., an assistant professor in the Division of General Internal Medicine at the John Hopkins University School of Medicine, "These agents are used by millions of Americans with diabetes. These new diabetes drugs are very effective in lowering blood glucose. However, important safety findings may not have been fully explored and some side effects such as acute pancreatitis didn't appear until widespread use after approval." FDA recommends patients to keep taking the prescribing drugs until further notice.

FDA notes that it "has not reached any new conclusions about safety risks with incretin mimetic drugs. This early communication is intended only to inform the public and healthcare professionals that the agency intends to obtain and evaluate this new information."

FDA says it is continuing to evaluate all available data to further understand this potential safety issue and will participate in the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) and National Cancer Institute (NCI) Workshop on Pancreatitis-Diabetes-Pancreatic Cancer in June 2013 to gather and share additional information.

FDA will communicate its final conclusions and recommendations when its review is complete or when the agency has additional information to report.

More Information available on the FDA website. 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 21 March, 2013 and appeared in  OncologyIssue 669

Past five issues: Diabetes Clinical Mastery Series Issue 216 | Issue 756 | Diabetes Clinical Mastery Series Issue 215 | SGLT-2 Inhibitors Special Edition November 2014 | Issue 755 |

2014 Most Popular Articles:

New SGLT2 Inhibitor Likely To Be Approved for Type 2 Diabetes
Posted November 14, 2014
New Approach Targets Type 2's Poorly Controlled With Metformin
Posted November 14, 2014
Grapefruit Juice May Affect Insulin Resistance
Posted October 23, 2014
Very Low Carbohydrate, Low Saturated Fat Diet for Type 2 Diabetes Management
Posted November 07, 2014
Dietary Magnesium Intake's Role in Decreasing Metabolic Syndrome
Posted October 31, 2014
Exercise Promotes Preservation of Beta Cells
Posted November 14, 2014
Handbook of Diabetes, 4th Ed., Excerpt #16: Diabetic Neuropathy
Posted November 02, 2014
FDA Accepts Filing of NDA for Empagliflozin/Metformin Fixed-dose Combination
Posted October 23, 2014
What's Hiding in that Insulin Box?
Posted October 27, 2014
Interview with NuSirt CEO Joe Cook, Jr: Improving Metformin Treatment, Part 1
Posted November 02, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Richard K. Bernstein, MD | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
If the U.S. Affordable Care Act is reversed in the new congress, what impact will that have on your patients?
CME/CE of the Week
Silvia Inzucchi, MD

Category: General Diabetes
Credits: .75
Search Articles On Diabetes In Control