Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted and appeared in  Women's HealthIssue 669

Two Glucose Uptake Mechanisms Affected by Polycystic Ovary Syndrome

Polycystic ovary syndrome (PCOS) poses a double impact in glucose control in women with the highest level of insulin resistance....

Advertisement

A recent study, compared 28 healthy women with 28 with PCOS showing that women with PCOS had a decrease in both insulin and non-insulin glucose controlling mechanisms. PCOS participants with the most insulin resistance at the start of the trial had results that showed a decline in their ability to compensate with non-insulin glucose controlling mechanisms.

Dr. Ricardo Azziz, reproductive endocrinologist and PCOS expert at Georgia Regents University, states, "Women with PCOS who have the highest levels of insulin resistance, the greatest difficulty controlling their sugar and the highest risk for diabetes, appear to have a double defect in how glucose is controlled, which affects both the mechanisms that use insulin and those that do not." The study measured visceral and subcutaneous fat distribution, which predicted the degree of insulin and non-insulin glucose control, respectively.

"If the fat is not as sensitive to insulin, that obviously means blood sugar levels, and probably fat and cholesterol levels as well, increase and the pancreas responds by producing more insulin," Azziz said. "Fat abnormalities can have a tremendous impact on how we feel and how we function."

In the future, the researchers want to construct a study that includes understanding the molecular mechanisms involved in how PCOS affects glucose usage.

Journal of Clinical Endocrinology & Metabolism, 2013; DOI: 10.1210/jc.2012-2937 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 21 March, 2013 and appeared in  Women's HealthIssue 669

Past five issues: Diabetes Clinical Mastery Series Issue 234 | Issue 774 | Diabetes Clinical Mastery Series Issue 233 | SGLT-2 Inhibitors Special Edition March 2015 | Issue 773 |

2015 Most Popular Articles:

FDA Approves Sanofi's Diabetes Drug Toujeo
Posted February 27, 2015
One Modification of Diet Can Improve the Metabolic Syndrome
Posted February 27, 2015
Eylea Bests Avastin, Lucentis in Diabetic Macular Edema
Posted February 27, 2015
Reduced GLP-1 Precedes Type 2 Diabetes
Posted March 05, 2015
'Smart' Insulin Holds Promise for Type 1 Diabetes Patients
Posted February 27, 2015
What Most Docs Don't Do: Counsel Patients on Drug Adherence
Posted February 27, 2015
Resistance Exercise after Dinner Decreases CVD Risk for Type 2's
Posted February 27, 2015
Breastfeeding May Lower Risk of Type 1 Diabetes
Posted February 27, 2015
Breakfast Habits Affect Overweight Teen Girls Metabolic Responses to Protein-Packed Morning Meals
Posted March 13, 2015
Quality Management in Diabetes Care
Posted February 27, 2015


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Richard K. Bernstein, MD | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
Are you interested in learning how to improve patient care by doing a reimbursable comprehensive diabetic foot exam?
CME/CE of the Week
Silvia Inzucchi, MD

Category: General Diabetes
Credits: .75
Search Articles On Diabetes In Control