Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted and appeared in  DietObesityBG ControlType 2 DiabetesPreventionGenetics of DiabetesOncologyPathologyPublic HealthIssue 663

Mechanism that Links Diabetes and Obesity with Cancer Discovered

Sustained high levels of sugars damage our cells and can….

Advertisement

Scientists led by Dr. Custodia Garcia-Jimenez at the University Rey Juan Carlos in Madrid have uncovered a key mechanism that links obesity and diabetes with cancer: high sugar levels, which increase the activity of a gene widely implicated in cancer progression.

Dr. Jimenez studied how cells in the intestine respond to sugars and signal to the pancreas to release insulin, the key hormone that controls blood sugar levels. Sugars in the intestine trigger cells to release a hormone called GIP that enhances insulin release by the pancreas.

In a published study, Dr. Garcia Jimenez's team showed that the ability of the intestinal cells to secrete GIP is controlled by a protein called β-catenin, and that the activity of β-catenin is strictly dependent on sugar levels.

Increased activity of β-catenin is known to be a major factor in the development of many cancers and can make normal cells immortal, a key step in early stages of cancer progression. The study demonstrates that high (but not normal) sugar levels induce nuclear accumulation of β-catenin and lead to cell proliferation. The β-catenin changes, the molecules involved, and the diversity of cancer cells susceptible to these changes are identified.

Dr. Custodia García said, "We were surprised to realize that changes in our metabolism caused by dietary sugar impact our cancer risk. We are now investigating what other dietary components may influence our cancer risk. Changing diet is one of the easiest prevention strategies that can potentially save a lot of suffering and money."

Colin Goding, Professor of Oncology at the University of Oxford, UK, said, "Previously we were unsure about how increased blood sugar found in diabetes and obesity could increase cancer risk. This study identifies a key molecular mechanism through which high blood glucose would predispose to cancer. It opens the way for potential novel therapies aimed at reducing cancer risk in the obese and diabetic populations."

Estimations published by the World Health Organization: obesity predisposes to diabetes and its prevalence is doubling every 20 years worldwide. More than 1 in 10 adults worldwide (12%) are obese (BMI greater than 30). One in 6 children in the UK and Spain suffer obesity.

More than half (63%) of premature deaths worldwide are due to non-communicable diseases of which cancer and diabetes are among the 4 most frequent causes. At least 1 in 3 of the main cancers (27-39%) can be prevented by improving diet, physical activity and body composition.

Molecular Cell Jan 2013 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 08 February, 2013 and appeared in  DietObesityBG ControlType 2 DiabetesPreventionGenetics of DiabetesOncologyPathologyPublic HealthIssue 663

Past five issues: Issue 783 | SGLT-2 Inhibitors Special Edition May 2015 | Diabetes Clinical Mastery Series Issue 242 | Issue 782 | GLP-1 Special Editions May 2015 |

2015 Most Popular Articles:

What Is the Medicare Diabetes Prevention Act?
Posted May 08, 2015
Neuropathy Due to Vitamin B-12 Deficiency, Not Diabetes
Posted April 30, 2015
Is Diet or Exercise the Best Way to Reduce Diabetes Risk?
Posted May 15, 2015
GLP-1 Analog May Help with NAFLD and Nonalcoholic Steatohepatitis
Posted May 15, 2015
Fish Oil May Help with Diabetic Neuropathy
Posted May 15, 2015
SGLT-2 Inhibitors: Teach from the Start and Manage Expectations
Posted May 03, 2015
Vitamin D Supplements May Help Patients Lose Weight
Posted May 15, 2015
Treating Sleep Apnea with CPAP Nightly Can Lower Diabetes Risk
Posted May 08, 2015
Summary of Standards of Care for Diabetes for Primary Care
Posted April 30, 2015
Metformin Reported in Use with Only 3.7% of Those with Prediabetes
Posted April 30, 2015


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Richard K. Bernstein, MD | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
Do you believe that the FDA takes too much time to approve a drug?
CME/CE of the Week
Guy Pupp, DPM, FACFAS

Category: Diabetic Foot
Credits:
 1.0
Search Articles On Diabetes In Control