Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted 15 November, 2012 and appeared in  Type 1 DiabetesPathologyIssue 652

Stem Cell Breakthrough May Bring Us Closer to a Cure

In a breakthrough that signifies a move toward a cure for type 1 diabetes, Australian researchers have identified stem cells in the pancreas that can be turned into insulin-producing cells....

Advertisement

The finding may bring closer the day when people with type 1 diabetes will be able to produce their own insulin and not have to inject it.

In their paper, Dr. Ilia Banakh and Professor Len Harrison from the Walter and Eliza Hall Institute's division of Molecular Medicine, and colleagues, describe how they identified and isolated stem cells from the adult pancreas, and then developed a way to coax them into insulin-producing cells that can secrete insulin in response to glucose.

Harrison explains in a separate statement how there have been previous successes at generating insulin-producing cells in the adult pancreas from cells with "stem-like" features, but what excites him about this find is that Banakh has pinpointed "the cell of origin of the insulin-producing cells and shown that the number of these cells and their ability to turn into insulin-producing cells increases in response to pancreas injury."

The researchers worked first with cells in the "test tube," and then tested the method in mice:

"Insulin expression was maintained when tissue was transplanted within vascularised chambers into diabetic mice," they write.

The researchers believe their discovery provides further evidence that stem cells don't only occur in the embryo and means people with type 1 diabetes may one day be able to regenerate their own insulin-producing cells.

The finding means the potential to regenerate insulin-producing cells is present in all of us, even as adults, says Harrison, a clinician scientist whose work is recognized was conferred the Outstanding Contribution to Diabetes Award.

"In the long-term, we hope that people with type 1 diabetes might be able to regenerate their own insulin-producing cells. This would mean that they could make their own insulin and regain control of their blood glucose levels, curing their diabetes," declares Harrison, adding that, "Of course, this strategy will only work if we can devise ways to overcome the immune attack on the insulin-producing cells, that causes diabetes in the first place."

Funds from the JDRF, the National Health and Medical Research Council of Australia and the Victorian Government helped finance the study.

"Adult Pancreas Side Population Cells Expand after β Cell Injury and Are a Source of Insulin-Secreting Cells"; Banakh I, Gonez LJ, Sutherland RM, Naselli G, Harrison LC; PLoS ONE 7(11): e48977, published online 9 Nov 2012; DOI:10.1371/journal.pone.0048977; 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 15 November, 2012 and appeared in  Type 1 DiabetesPathologyIssue 652

Past five issues: Issue 744 | Diabetes Clinical Mastery Series Issue 203 | Issue 743 | Diabetes Clinical Mastery Series Issue 202 | SGLT-2 Inhibitors Special Edition August 2014 |

2014 Most Popular Articles:

Low-carb Diet Recommended for Type 1 and 2 Diabetes Patients
Posted August 01, 2014
New Combination of Diabetes Drugs Have Synergistic Effect
Posted August 08, 2014
FDA Approves J&J's Invokamet Combo (SGLT-2 + Metformin)
Posted August 15, 2014
New Encapsulated Beta-Cell Replacement Therapy for Type 1 Diabetes
Posted August 08, 2014
Diabetic Neuropathy Improved with Vegan Diet
Posted August 22, 2014
During Prolonged Low-Intensity Exercise, Caffeine Alters Blood Glucose
Posted August 15, 2014
CDC: 40% of American Adults Will Develop Diabetes
Posted August 22, 2014
SGLT2 Inhibitor Empagliflozin Wins FDA OK
Posted August 08, 2014
HbA1c Increases with Age
Posted August 01, 2014
Early Insulin Delays Diabetes But Are There Negative Consequences?
Posted August 15, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Bernstein | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
When Afrezza is available, will you prescribe it immediately or wait until it has been on the market for a while?
CME/CE of the Week
Dr. Michael Miller, Dr. Sergio Fazio, and Dr. Roger Blumenthal

Category: Cardiology
Credits:
 1
Search Articles On Diabetes In Control