Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted 15 November, 2012 and appeared in  Type 1 DiabetesPathologyIssue 652

Stem Cell Breakthrough May Bring Us Closer to a Cure

In a breakthrough that signifies a move toward a cure for type 1 diabetes, Australian researchers have identified stem cells in the pancreas that can be turned into insulin-producing cells....

Advertisement

The finding may bring closer the day when people with type 1 diabetes will be able to produce their own insulin and not have to inject it.

In their paper, Dr. Ilia Banakh and Professor Len Harrison from the Walter and Eliza Hall Institute's division of Molecular Medicine, and colleagues, describe how they identified and isolated stem cells from the adult pancreas, and then developed a way to coax them into insulin-producing cells that can secrete insulin in response to glucose.

Harrison explains in a separate statement how there have been previous successes at generating insulin-producing cells in the adult pancreas from cells with "stem-like" features, but what excites him about this find is that Banakh has pinpointed "the cell of origin of the insulin-producing cells and shown that the number of these cells and their ability to turn into insulin-producing cells increases in response to pancreas injury."

The researchers worked first with cells in the "test tube," and then tested the method in mice:

"Insulin expression was maintained when tissue was transplanted within vascularised chambers into diabetic mice," they write.

The researchers believe their discovery provides further evidence that stem cells don't only occur in the embryo and means people with type 1 diabetes may one day be able to regenerate their own insulin-producing cells.

The finding means the potential to regenerate insulin-producing cells is present in all of us, even as adults, says Harrison, a clinician scientist whose work is recognized was conferred the Outstanding Contribution to Diabetes Award.

"In the long-term, we hope that people with type 1 diabetes might be able to regenerate their own insulin-producing cells. This would mean that they could make their own insulin and regain control of their blood glucose levels, curing their diabetes," declares Harrison, adding that, "Of course, this strategy will only work if we can devise ways to overcome the immune attack on the insulin-producing cells, that causes diabetes in the first place."

Funds from the JDRF, the National Health and Medical Research Council of Australia and the Victorian Government helped finance the study.

"Adult Pancreas Side Population Cells Expand after β Cell Injury and Are a Source of Insulin-Secreting Cells"; Banakh I, Gonez LJ, Sutherland RM, Naselli G, Harrison LC; PLoS ONE 7(11): e48977, published online 9 Nov 2012; DOI:10.1371/journal.pone.0048977; 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 15 November, 2012 and appeared in  Type 1 DiabetesPathologyIssue 652

Past five issues: Diabetes Clinical Mastery Series Issue 184 | Issue 724 | Diabetes Clinical Mastery Series Issue 183 | Issue 723 | Diabetes Clinical Mastery Series Issue 182 |

2014 Most Popular Articles:

Patient Handout: 7 Tips to Drop Excess Pounds with Diabetes
Posted April 04, 2014
Who Qualifies for Statin Treatment under the New Guidelines?
Posted March 27, 2014
Vitamin D's Effect on the Progression of Pre-type 1 Diabetes
Posted March 14, 2014
Updated Bolus Calculators for Diabetes Management
Posted March 20, 2014
A1C Is a Predictor of Clinical Outcomes Following Noncardiac Surgery
Posted March 14, 2014
Abdominal Fat Accumulation Prevented by Unsaturated Fat
Posted March 14, 2014
Evidence Shows Possible Benefit of Metformin and Glyburide Use in Pregnancy
Posted March 14, 2014
Surprising Trends in the Use of Antidiabetic Drugs
Posted March 27, 2014
Statin Side-effects Questioned
Posted March 20, 2014
Certain Complications of Obesity May Be Linked to Pollutants
Posted March 14, 2014

See more most popular…


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Bernstein | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |
Advertisement

Cast Your Vote
Was the data release from CMS on Medicare payments a good idea?
CME/CE of the Week
Dr. Michael Miller, Dr. Sergio Fazio, and Dr. Roger Blumenthal

Category: Cardiology
Credits:
 1
Search Articles On Diabetes In Control