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This article originally posted and appeared in  MedicationBG ControlPreventionIssue 568Special Edition - Best of 2011

Nicotine Can Raise A1c by 34 Percent

Strong link between nicotine and diabetes complications....
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Scientists have reported the first strong evidence implicating nicotine as the main culprit responsible for persistently elevated blood sugar levels -- and the resulting increased risk of serious health complications -- in people who have diabetes and smoke. 

The discovery also may have implications for people with diabetes who are using nicotine-replacement therapy for extended periods in an attempt to stop smoking.

Xiao-Chuan Liu, Ph.D., who presented the results stated that, "This is an important study and it is the first study to establish a strong link between nicotine and diabetes complications. If you're a smoker and have diabetes, you should be concerned and make every effort to quit smoking."

Doctors have known for years that smoking increases the risk of developing complications. Studies also show that smokers with diabetes have higher levels of HbA1c than nonsmokers with diabetes. However, nobody knew the exact substance in cigarette smoke responsible for the elevation in HbA1c. Liu and colleagues suspected it may be nicotine and set out to check nicotine's effects on HbA1c. Using human blood samples, they showed that concentrations of nicotine similar to those found in the blood of smokers did, indeed, raise levels of HbA1c.

"Nicotine caused levels of HbA1c to rise by as much as 34 percent," said Liu, who is with California State Polytechnic University in Pomona, Calif. "No one knew this before. The higher the nicotine levels, the more HbA1c is produced."

Doctors could use data from this study as a new basis for encouraging patients with diabetes to quit smoking, Liu said. What about nicotine patches, electronic cigarettes, and other stop-smoking products? Liu pointed out that people tend to use those products for only brief periods, and that the benefits of permanently stopping smoking may outweigh any risk from temporary elevations in HbA1c. However, the study may raise concern over the long term use of such products, he added.

Presented at the 241st National Meeting & Exposition of the American Chemical Society

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This article originally posted 05 April, 2011 and appeared in  MedicationBG ControlPreventionIssue 568Special Edition - Best of 2011

Past five issues: Diabetes Clinical Mastery Series Issue 212 | GLP-1 Special Editions October 2014 | Issue 752 | SGLT-2 Inhibitors Special Edition October 2014 | Diabetes Clinical Mastery Series Issue 211 |

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