In people with insulin-dependent type 1 diabetes, exercise does not appear to
increase the rate of absorption of insulin glargine (Lantus), a long-acting insulin
analog, according to study findings.
Dr. David R. Owens, of Llandough Hospital, South Glamorgan, Wales, stated that
"This study suggests that insulin glargine can be safely and effectively
administered without a dose change during exercise." However, they note that
the study does not rule out the possibility of late exercise-induced low blood
sugar, also called hypoglycemia, and "insulin glargine reduction may be warranted
depending on individual patient responses."
The investigators compared the effect of exercise on the absorption of injected
insulin glargine in 13 patients with type 1 diabetes. The usual insulin dose was
given in the thigh on the evening before the exercise study on two occasions 1
week apart.
The patients were randomized to 30 minutes of intense exercise, 1 hour after a
meal. They compared the decay of radiolabeled insulin glargine on the two occasions
and they collected blood samples to assess blood sugar and insulin profiles.
As expected, the investigators observed a significant fall in blood sugar on the
exercise day during the exercise period. However, no significant difference was
observed in the rate of insulin glargine decay on the 2 study days (exercise versus
no exercise).
The team cautions against over interpreting these results, noting that real-world
exercise activity may have different effects on glargine absorption.
Diabetes Care March 2005.
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