Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted 29 May, 2014 and appeared in  BG ControlType 2 DiabetesGLP-1Issue 731GLP-1 Special Editions June 2014GLP-1 Special Editions Summer 2014

AACE: Dulaglutide Predicts HBA1c with Fasting Blood Glucose at 2 Weeks

A study conducted in patients with type 2 diabetes receiving dulaglutide has shown that fasting blood glucose levels 2 weeks after beginning treatment are predictive of long-term glucose control as measured by HbA1c 6 months later.... 

Advertisement

The results are based on post hoc analyses of 2 double-blinded, randomized phase III studies, AWARD-1 and AWARD-5. The AWARD-1 study compared the safety and efficacy of placebo, dulaglutide and exenatide in patients with type 2 diabetes on metformin and pioglitazone. The AWARD-5 study compared the safety and efficacy of placebo, dulaglutide and sitagliptin in patients with type 2 diabetes on metformin.

The primary outcome measure was reduction of HbA1c from baseline to 26 weeks (AWARD-1) or 52 weeks (AWARD-5). Both doses of dulaglutide examined in these studies (0.75 mg and 1.5 mg) significantly reduced HbA1c compared to the respective comparison drugs.

In AWARD-5, 3 categories of fasting blood glucose levels defined at baseline: low (less than 142 mg/dL), intermediate (between 142 and 185 mg/dL) and high (more than 185 mg/dL). At baseline, mean fasting blood glucose was 176 mg/dL. Patients were roughly evenly distributed in each group; 33% (n = 99) were in the low group, 32% (n = 97) in the intermediate group, and 36% (n = 108) in the high group. After two weeks of treatment with 1.5 mg dulaglutide, mean fasting blood glucose was 129 mg/dL and an increased number of patients were in the low group: 68% (n = 208) in the low group, 21% (n = 64) in the intermediate group, and 11% (n = 32) in the high group.

At baseline, the mean HbA1c was 8.1% (n = 304). At week 26 of the study, mean HbA1c was 6.9%. Fasting blood glucose at week 2 was strongly associated with achieving an HbA1c of <7.0% at week 26. A greater number of patients in the low category at week 2 achieved an A1c of <7.0% at week 26. The AWARD-1 data analysis produced similar results.

George Grunberger, MD, of the Grunberger Diabetes Institute, in Bloomfield Hills, Michigan, who published the findings added that, "We found out in the two studies that one could predict the eventual glycemic improvement by dulaglutide already after examining fall in fasting plasma glucose levels after 2 weeks." "If confirmed in other studies, clinicians could predict responders early on and perhaps decide whether to continue dulaglutide therapy or look for another modality much sooner than 8-10 weeks."

Practice Pearls:
  • Dulaglutide has shown that fasting blood glucose levels 2 weeks after beginning treatment are predictive of long-term glucose control
  • The eventual glycemic improvement by dulaglutide could be predicted after examining fall in fasting plasma glucose levels after 2 weeks.
  • This is preliminary information and needs to be studied further.

The findings were presented at the American Association of Clinical Endocrinologists annual meeting held from May 14th to 18th in Las Vegas, Nevada. 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 29 May, 2014 and appeared in  BG ControlType 2 DiabetesGLP-1Issue 731GLP-1 Special Editions June 2014GLP-1 Special Editions Summer 2014

Past five issues: Diabetes Clinical Mastery Series Issue 199 | Issue 739 | GLP-1 Special Editions July 2014 | Diabetes Clinical Mastery Series Issue 198 | Issue 738 |

2014 Most Popular Articles:

U.S. FDA Approves Inhaled Insulin: What Medical Professionals Need to Know
Posted July 04, 2014
Newly Updated: Comprehensive List of Insulins
Posted June 30, 2014
Can Insulin Treatment Do More Harm Than Good for Older Type 2's?
Posted July 04, 2014
Too Much Medication for Elderly Diabetes Patients?
Posted July 11, 2014
Pluses and Minuses of Glucose Lowering for Older Diabetes Patients
Posted July 18, 2014
Which Is Better for BG Control: Aerobic or Anaerobic Exercise?
Posted July 11, 2014
HbA1c Variability and Mortality in Patients with Type 2 Diabetes
Posted July 18, 2014
Role of Leptin Deficiency in Type 1 Diabetes
Posted July 11, 2014
Association between Diabetic Foot Ulceration and Premature Death
Posted July 04, 2014
One Possible Answer to Healing Chronic Diabetic Foot Ulcers
Posted July 04, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Bernstein | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |
Cast Your Vote
Do you offer group education sessions in your practice?
CME/CE of the Week
Vickie Driver, DPM, MS, FACFAS

Category: Wound Care
Credits: 1.0



Search Articles On Diabetes In Control