Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted and appeared in  Women's HealthIssue 730

Liver Enzymes Can Predict Gestational Diabetes Risk

Women with high levels of the liver enzyme gamma-glutamyl transferase before pregnancy may be more likely to develop gestational diabetes than those with lower levels.... 

Advertisement

Sneha B. Sridhar, MPH, of the division of research at Kaiser Permanente Northern California in Oakland, and colleagues compared medical records of 256 women who developed gestational diabetes with 497 women who did not develop gestational diabetes.

Sridhar said in a press release, "A few studies have looked at liver enzyme levels during pregnancy and the risk of gestational diabetes." "But, to our knowledge, this is the first to look at liver enzyme levels measured before pregnancy."

All of the women had participated in the Kaiser Permanente Northern California multiphasic health checkup (1984-1996) and had a subsequent pregnancy (1984-2009). Control participants were selected and matched based on year of blood draw (±3 months), age at examination (±2 years), number of intervening pregnancies (0, 1, ≥2) and age at delivery of index pregnancy (±2 years).

The highest quartile vs. the lowest quartile of gamma-glutamyl transferase (GGT) was associated with a twofold increased risk for subsequent gestational diabetes (OR=1.97; 95% CI, 1.14-3.42), after adjusting for race/ethnicity, pre-pregnancy BMI, family history of diabetes and alcohol use. When adjusted for homeostasis model assessment of insulin resistance (HOMA-IR), fasting status and rate of gestational weight gain, the results were diminished.

"The association appeared to be moderated by increased insulin resistance, and in the stratified analysis, it was present only among women who were in the top tertile of HOMA-IR before pregnancy," the researchers wrote.

No associations were found with two other commonly monitored liver enzymes, alanine aminotransferase and aspartate aminotransferase.

The researchers suggest a risk model to monitor GGT levels before pregnancy could identify women who might benefit from interventions even before conceiving.

Practice Pearls:
  • Consider monitoring GGT levels before pregnancy
  • No associations were found with two other commonly monitored liver enzymes, alanine aminotransferase

Sridhar SB. Diabetes Care. 2014;doi:10.2337/dc13-2229. 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 23 May, 2014 and appeared in  Women's HealthIssue 730

Past five issues: Diabetes Clinical Mastery Series Issue 219 | Issue 759 | Diabetes Clinical Mastery Series Issue 218 | GLP-1 Special Editions December 2014 | Issue 758 |

2014 Most Popular Articles:

Handbook of Diabetes, 4th Ed., Excerpt #20: Foot Problems in Diabetes
Posted November 29, 2014
Is Type 2 Diabetes an Inflammatory Disease?
Posted November 21, 2014
Handbook of Diabetes, 4th Ed., Excerpt #19: Macrovascular Disease in Diabetes
Posted November 23, 2014
Why Are Up to 20% Type 2's Nonresponsive to Exercise?
Posted December 05, 2014
Any Pain Medication Said Effective When Treating Diabetic Nerve Pain
Posted November 21, 2014
New Approach Targets Type 2's Poorly Controlled With Metformin
Posted November 14, 2014
New Guidelines for Doctors to Treat Diabetes
Posted December 12, 2014
Carbs Associated with Higher Diabetes and Heart Disease Risk Factor
Posted December 05, 2014
Link between Free Fatty Acids and Acute MI, Type 2 Diabetes
Posted November 21, 2014
Knowledge of Onset, Peak, and Duration of Action of Meds Prevents a Trip to the ER
Posted November 24, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Richard K. Bernstein, MD | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
How many of your prediabetic patients have delayed diabetes for more than 5 years with only lifestyle changes?
CME/CE of the Week
Marie Williams, DPM

Category: Wound Care
Credits: .75



Search Articles On Diabetes In Control