Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted 16 May, 2014 and appeared in  MedicationType 2 DiabetesGLP-1Issue 729GLP-1 Special Editions May 2014GLP-1 Special Editions June 2014

Chronic Twice-daily Exenatide Treatment on Beta Cell Function in New-onset T2DM

Improvements seen in peripheral insulin sensitivity and hepatic insulin extraction….

Advertisement

Researchers conducted a 24-week, randomized, double-blinded, placebo-controlled, multicenter study with 79 participants given an oral glucose tolerance test at baseline before starting treatment and after 24 weeks of treatment. Participants were asked to report to their clinical testing site in the morning after an overnight fast of 10-12 hours.

The results of the trial showed that all groups lost significant amounts of weight around 2-5 kilograms, but when compared to the placebo, 24-weeks of daily high or low doses reduced HbA1c and additionally, improved fasting and postprandial hyperglycemia as well. Exenatide was associated with an improved peripheral insulin sensitivity and hepatic insulin resistance index free of changes in weight. Plasma insulin levels and insulin secretion rates, however, during the oral glucose tolerance test did not differ before or after treatment with exenatide or placebo. Exenatide when given in the higher dose was associated with a significant improvement in beta cell sensitivity to glucose, and reduced hepatic insulin extraction. The P value was less than 0.05, labeling this study as statistically significant.

According to the results of this study, a patient with new onset type 2 diabetes given exenatide chronically will experience enhanced insulin secretion rates, and increased beta cell sensitivity to glucose. Although these improvements are seen in the beta cell function, the plasma insulin and C-peptide levels do not necessarily reflect so.

Practice Pearls:
  • When given exenatide chronically it enhances insulin secretion rates, and increases beta cell sensitivity to glucose
  • Improvements when giving exenatide chronically is seen in the beta cell function but does not reflect in the plasma insulin and C-peptide levels
  • Patients taking exenatide in this study also showed significant weight loss, around 2-5 kilograms.

Gastaldelli, Amalia, Robert G. Brodows, and David D'Alessio. "The Effect of Chronic Twice Daily Exenatide Treatment on β-cell Function in New Onset Type 2 Diabetes." Clin Endocrinol. 2014;80(4):545-553.  

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 16 May, 2014 and appeared in  MedicationType 2 DiabetesGLP-1Issue 729GLP-1 Special Editions May 2014GLP-1 Special Editions June 2014

Past five issues: Diabetes Clinical Mastery Series Issue 199 | Issue 739 | GLP-1 Special Editions July 2014 | Diabetes Clinical Mastery Series Issue 198 | Issue 738 |

2014 Most Popular Articles:

U.S. FDA Approves Inhaled Insulin: What Medical Professionals Need to Know
Posted July 04, 2014
Newly Updated: Comprehensive List of Insulins
Posted June 30, 2014
Can Insulin Treatment Do More Harm Than Good for Older Type 2's?
Posted July 04, 2014
Too Much Medication for Elderly Diabetes Patients?
Posted July 11, 2014
Which Is Better for BG Control: Aerobic or Anaerobic Exercise?
Posted July 11, 2014
Pluses and Minuses of Glucose Lowering for Older Diabetes Patients
Posted July 18, 2014
Association between Diabetic Foot Ulceration and Premature Death
Posted July 04, 2014
HbA1c Variability and Mortality in Patients with Type 2 Diabetes
Posted July 18, 2014
Role of Leptin Deficiency in Type 1 Diabetes
Posted July 11, 2014
One Possible Answer to Healing Chronic Diabetic Foot Ulcers
Posted July 04, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Bernstein | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |
Cast Your Vote
Do you offer group education sessions in your practice?
CME/CE of the Week
Warren Joseph, DPM, FIDSA

Category: Wound Care
Credits: .75



Search Articles On Diabetes In Control