Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted and appeared in  Culturally Aware CareWomen's HealthType 2 DiabetesChildren & TeensIssue 729

Maternal Diabetes Increases Risk for Type 2 Diabetes Children

Exposure to diabetes in utero may significantly impair beta-cell function in children.... 

Advertisement

Steven D. Chernausek, MD, associate chief of the pediatric diabetes and endocrinology section, the University of Oklahoma College of Medicine stated that, "We found that if the child is born to a mother with diagnosis either before or during the pregnancy, that child presented at a younger age with a diagnosis of diabetes, had measurable deterioration in glucose control, higher blood glucose on oral glucose tolerance tests, had higher HbA1c, and that this was all due to an effect on beta-cell function, not on insulin sensitivity."

"What we found was that the impact of the mother's diabetes on the beta cell was only apparent in non-Hispanic blacks and Hispanics. It wasn't apparent in Caucasians, and that was a surprising finding."

The TODAY study, a large well-controlled study looking at young, well-controlled adolescents with diabetes, was used in this analysis to look specifically at the effect on those patients born to women with diabetes in pregnancy.

Children born to mothers with diabetes had higher HbA1c and fasting blood glucose at baseline (P<.0001), and C-peptide index and oral disposition index, both of which were used as measures of beta-cell function, were decreased (P≤.0001). Pair-wise comparisons showed these effects were only present in non-Hispanic black and Hispanic participants (all P<.01).

Chernausek added that, "We've known for a long time there's differences in diabetes in Caucasians compared to Hispanics; there are differences of metabolic control." "This is another sign that type 2 diabetes is different in the Hispanic, non-Hispanic black populations. It manifests in different ways and they're susceptible to different things."

Practice Pearls:
  • Type 2 diabetes in utero significantly impairs beta-cell function in children.
  • The results of this study are preliminary and no conclusions should be made until it has been reviewed and published.
  • Type 2 diabetes is different in the Hispanic, non-Hispanic black populations.

Presented at: the Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting; May 3-6, 2014; Vancouver, British Columbia. 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 16 May, 2014 and appeared in  Culturally Aware CareWomen's HealthType 2 DiabetesChildren & TeensIssue 729

Past five issues: Issue 782 | Diabetes Clinical Mastery Series Issue 241 | issue 781 | Diabetes Clinical Mastery Series Issue 240 | Issue 780 |

2015 Most Popular Articles:

Neuropathy Due to Vitamin B-12 Deficiency, Not Diabetes
Posted April 30, 2015
What Is the Medicare Diabetes Prevention Act?
Posted May 08, 2015
Is Diet or Exercise the Best Way to Reduce Diabetes Risk?
Posted May 15, 2015
Metformin Reported in Use with Only 3.7% of Those with Prediabetes
Posted April 30, 2015
Statin Therapy Associated with 46% Higher Risk of Type 2 Diabetes
Posted April 23, 2015
Summary of Standards of Care for Diabetes for Primary Care
Posted April 30, 2015
SGLT-2 Inhibitors: Teach from the Start and Manage Expectations
Posted May 03, 2015
Treating Sleep Apnea with CPAP Nightly Can Lower Diabetes Risk
Posted May 08, 2015
How to Lower the Risk of Getting Diabetes by Up to 25%
Posted May 08, 2015
Fish Oil May Help with Diabetic Neuropathy
Posted May 15, 2015


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Richard K. Bernstein, MD | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
Do you believe that we could have a bionic pancreas by 2017?
CME/CE of the Week
Warren Joseph, DPM, FIDSA

Category: Wound Care
Credits: .75



Search Articles On Diabetes In Control