Sign up for our complimentary
weekly e-journal

Main Newsletter
Mastery Series
Therapy Series
 
Bookmark and Share | Print Article | Items for the Week Previous | All Articles This Week | Next
This article originally posted 16 May, 2014 and appeared in  Culturally Aware CareWomen's HealthType 2 DiabetesChildren & TeensIssue 729

Maternal Diabetes Increases Risk for Type 2 Diabetes Children

Exposure to diabetes in utero may significantly impair beta-cell function in children.... 

Advertisement

Steven D. Chernausek, MD, associate chief of the pediatric diabetes and endocrinology section, the University of Oklahoma College of Medicine stated that, "We found that if the child is born to a mother with diagnosis either before or during the pregnancy, that child presented at a younger age with a diagnosis of diabetes, had measurable deterioration in glucose control, higher blood glucose on oral glucose tolerance tests, had higher HbA1c, and that this was all due to an effect on beta-cell function, not on insulin sensitivity."

"What we found was that the impact of the mother's diabetes on the beta cell was only apparent in non-Hispanic blacks and Hispanics. It wasn't apparent in Caucasians, and that was a surprising finding."

The TODAY study, a large well-controlled study looking at young, well-controlled adolescents with diabetes, was used in this analysis to look specifically at the effect on those patients born to women with diabetes in pregnancy.

Children born to mothers with diabetes had higher HbA1c and fasting blood glucose at baseline (P<.0001), and C-peptide index and oral disposition index, both of which were used as measures of beta-cell function, were decreased (P≤.0001). Pair-wise comparisons showed these effects were only present in non-Hispanic black and Hispanic participants (all P<.01).

Chernausek added that, "We've known for a long time there's differences in diabetes in Caucasians compared to Hispanics; there are differences of metabolic control." "This is another sign that type 2 diabetes is different in the Hispanic, non-Hispanic black populations. It manifests in different ways and they're susceptible to different things."

Practice Pearls:
  • Type 2 diabetes in utero significantly impairs beta-cell function in children.
  • The results of this study are preliminary and no conclusions should be made until it has been reviewed and published.
  • Type 2 diabetes is different in the Hispanic, non-Hispanic black populations.

Presented at: the Pediatric Academic Societies and Asian Society for Pediatric Research joint meeting; May 3-6, 2014; Vancouver, British Columbia. 

Advertisement


 

Bookmark and Share | Print | Category | Home

This article originally posted 16 May, 2014 and appeared in  Culturally Aware CareWomen's HealthType 2 DiabetesChildren & TeensIssue 729

Past five issues: Issue 744 | Diabetes Clinical Mastery Series Issue 203 | Issue 743 | Diabetes Clinical Mastery Series Issue 202 | SGLT-2 Inhibitors Special Edition August 2014 |

2014 Most Popular Articles:

Low-carb Diet Recommended for Type 1 and 2 Diabetes Patients
Posted August 01, 2014
New Combination of Diabetes Drugs Have Synergistic Effect
Posted August 08, 2014
FDA Approves J&J's Invokamet Combo (SGLT-2 + Metformin)
Posted August 15, 2014
New Encapsulated Beta-Cell Replacement Therapy for Type 1 Diabetes
Posted August 08, 2014
Diabetic Neuropathy Improved with Vegan Diet
Posted August 22, 2014
During Prolonged Low-Intensity Exercise, Caffeine Alters Blood Glucose
Posted August 15, 2014
CDC: 40% of American Adults Will Develop Diabetes
Posted August 22, 2014
SGLT2 Inhibitor Empagliflozin Wins FDA OK
Posted August 08, 2014
Early Insulin Delays Diabetes But Are There Negative Consequences?
Posted August 15, 2014
Peripheral Neuropathy Associated with CV Disease and Stroke in Type 2 Diabetes Patients
Posted August 15, 2014


Browse by Feature Writer & Article Category.
A. Lee Dellon, MD | Aaron I. Vinik, MD, PhD, FCP, MACP | Beverly Price | Charles W Martin, DD | Derek Lowe, PhD | Dr. Bernstein | Dr. Brian Jakes, Jr. | Dr. Fred Pescatore | Dr. Tom Burke, Ph.D | Eric S. Freedland | Evan D. Rosen | Ginger Kanzer-Lewis | Greg Milliger | Kristina Sandstedt | Laura Plunkett | Leonard Lipson, M.A. | Louis H. Philipson | Maria Emanuel Ryan, DDS, PhD | Marilyn Porter, RD, CDE | Melissa Diane Smith | Michael R. Cohen, RPh, MS, ScD, FASHP | Paul Chous, M.A., OD | Philip A. Wood PhD | R. Keith Campbell, Professor, B.Pharm, MBA, CDE | Sheri R. Colberg PhD | Sherri Shafer | Stanley Schwartz, MD, FACP, FACE | Steve Pohlit | Steven V. Edelman, M.D. | Timothy S. Hollingshead |

Cast Your Vote
When Afrezza is available, will you prescribe it immediately or wait until it has been on the market for a while?
CME/CE of the Week
Warren Joseph, DPM, FIDSA

Category: Wound Care
Credits: .75



Search Articles On Diabetes In Control