The best outcomes were achieved by multiple daily injections with self-monitoring of blood glucose….
Researchers evaluated 96 c-peptide negative type 1 diabetic patients with impaired awareness of hypoglycemia. The participants were followed for 24 weeks and were randomly assigned to either of four different groups. A comparison between continuous subcutaneous insulin infusion and multiple daily injections including self monitoring of blood glucose.
Results showed there was a decrease overall in hypoglycemic events with improvement in hypoglycemia awareness. There was not any significant difference found between continuous subcutaneous infusion and multiple daily injections however.
The primary outcome of the study is to prevent the severe condition of hypoglycemia without worsening metabolic control.
Researchers believe the primary outcome is achieved by multiple daily injections with self-monitoring of blood glucose.
- Overall improvement of hypoglycemia awareness occurs with self-monitoring on blood glucose.
- There was no significant difference found between continuous insulin infusion and multiple daily injections when it comes to hypoglycemia awareness.
- Prevention of severe hypoglycemia events can decrease the risk of worsening metabolic control overall.
Little SA, Leelarathna L, Walkinshaw E, et al. Recovery of Hypoglycemia Awareness in Long-Standing Type 1 Diabetes: A Multicenter 2 x 2 Factorial Randomized Controlled Trial Comparing Insulin Pump With Multiple Daily Injections and Continuous With Conventional Glucose Self-Monitoring. Diabetes Care. 2014 May 22.