ASIAN GINSENG

Common Names
Korean ginseng, Chinese ginseng

Botany
Asian ginseng is a member of the Araliaceae family, which also includes the closely related American ginseng, Panax quinquefolius, and less similar Siberian ginseng, Eleutherococcus senticosus, also known as eleuthero. Asian ginseng commonly grows on mountain slopes and is usually harvested in the fall. The root is used, preferably from plants older than six years of age.

Historical or Traditional Use
Asian ginseng has been a part of Chinese medicine for over 2,000 years. The first reference to the health-enhancing use of Asian ginseng dates to the first century A.D., in which the writer mentions ginseng’s use as follows: “It is used for repairing the five viscera, quieting the spirit, curbing the emotion, stopping agitation, removing noxious influence, brightening the eyes, enlightening the mind and increasing wisdom. Continuous use leads one to longevity with light weight.” Ginseng was commonly used by elderly persons in the Orient to improve mental and physical vitality.

Active Constituents and Proposed Mechanism of Action
Ginseng’s actions in the body are due to a complex interplay of constituents. The primary group are the ginsenosides, which are believed to increase energy, counter the effects of stress, and enhance intellectual and physical performance. Thirteen ginsenosides have been identified in Asian ginseng. Ginsenosides Rg1 and Rb1 have received the most attention.1 Other constituents include the panaxans, which help lower blood sugar, and the polysaccharides (complex sugar molecules), which support immune function.2 3

Long-term intake may be linked to a reduced risk of cancer.4 A double-blind study has confirmed Asian ginseng’s blood sugar lowering effects in patients with adult diabetes.5 Human studies have mostly failed to confirm the purported benefit of Asian ginseng for the enhancement of athletic performance.6 Some studies suggest it may help those in poor physical condition tolerate exercise better.7 It does appear to effectively reduce fatigue in double-blind studies.8 A double-blind study has confirmed it is helpful for relief of fatigue and possible stress.9

Recommended Dosage
The best researched form of ginseng is standardized herbal extracts that supply approximately 5–7% ginsenosides; more concentrated extracts may be less effective due to reduction of panaxan levels.10 People often take 100–200 mg per day. Nonstandardized extracts require a higher intake, generally 1–2 grams per day for tablets or 2–3 ml for dried root tincture TID. Ginseng is usually used for two to three weeks continuously, followed by a one to two week “rest” period before resuming.

Contraindications
Used in the recommended amounts, ginseng is generally safe. In rare instances, it may cause overstimulation and possibly insomnia.11 Consuming caffeine with ginseng increases the risk of over-stimulation and gastrointestinal upset. Persons with uncontrolled high blood pressure should not use ginseng. Long-term use of ginseng may cause menstrual abnormalities and breast tenderness in some women. Ginseng is not recommended for pregnant or lactating women.

References:

1. Shibata S, Tanaka O, et al. Chemistry and pharmacology of Panax. In Economic and Medicinal Plant Research, vol 1, ed. H Wagner, H Hikino, NR Farnsworth. London: Academic Press, 1985, 217–84.
2. Tomoda M, Hirabayashi K, et al. Characterisation of two novel polysaccharides having immunological activities from the root of Panax ginseng. Biol Pharm Bull 1993;16:1087–90.
3. See DM, Broumand N, Sahi L, et al. In vitro effects of echinacea and ginseng on natural killer and antibody-dependent cell cytotoxicity in healthy subjects and chronic fatigue syndrome or acquired immunodeficiency syndrome patients. Immunopharmacol 1997;35:229–35.
4. Yun TK, Choi Y. Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs. Cancer Epidem Biomarkers Prev 1995;4:401–8.
5. Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non-insulin-dependent diabetic patients. Diabetes Care 1995;18:1373-5.
6. Teves MA, Wright JE, Welch MJ, et al. Effects of ginseng on repeated bouts of exhaustive exercise. Med Sci Sports Exerc 1983;15:162.
7. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals and trace elements on physical performance during exercise. Clin Ther 1991;13:373–82.
8. Le Gal M, Cathebras P, Struby K. Pharmaton capsules in the treatment of functional fatigue: A double-blind study versus placebo evaluated by a new methodology. Phytother Res 1996;10:49–53.
9. Caso Mardsco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C. Double-blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp Clin Res 1996;22:323–9.
10. Brown DJ. Herbal Prescriptions for Better Health. Rocklin, CA: Prima Publishing, 1996, 129–38.
11. Newall CA, Anderson LA, Phillipson JD. Herbal Medicines: A Guide for Healthcare Professionals. London: Pharmaceutical Press, 1996, 145–50.

 

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