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An Alternative Option for Weight and Glycemia Reduction

Sep 19, 2020
Editor: David L. Joffe, BSPharm, CDE, FACA

Author: Nour Salhab, Pharm.D. Candidate, USF College of Pharmacy

GOP hormone infusion could help in reducing patient weight and glucose levels. 

Roux-en-Y gastric surgery (RYGB) is known to be the most efficacious treatment for obesity and type 2 diabetes (T2DM). Increased postprandial secretions of Glucagon-like peptide 1 (GLP-1), Oxyntomodulin (OXM), and peptide YY (PYY) are one of the possible mechanisms of weight loss. These gut hormones have a synergistic effect on decreasing food intake and increasing satiety. Previous studies have shown that a continuous subcutaneous infusion of those hormones led to a reduction in total ad libitum energy intake. The purpose of the study was to determine whether the infusion of the GLP-1 agonist, Oxyntomodulin, and peptide YY (GOP) would reduce body weight and improve glycemia....

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