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GLP-1 Contraindications

Aug 12, 2017

Which of the following are strict or relative contraindications to the use of some of the GLP-1 agonists?


Answer: D. All of the above.


Explanation: In animal studies, some of the GLP-1 agonists have been linked with the development of medullary thyroid carcinoma. Therefore, some GLP-1 agonists are strictly contraindicated in patients with MEN syndrome type 2 or personal or family history of thyroid cancer, as these conditions can increase the risk of developing thyroid carcinomas. Furthermore, GLP-1 agonists have not been studied in patients with a history of pancreatitis. Because they do affect the pancreas and the relative paucity of studies, GLP-1 agonists are relatively contraindicated in this patient population as well.--

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